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Darnell, Malin, et al.
(författare)
Lipopolysaccharide induced-in vivo increases in beta-defensins of the rat parotid gland.
2006
Ingår i: Archives of oral biology. - : Elsevier BV. - 0003-9969. ; 51:9, s. 769-74
Tidskriftsartikel (refereegranskat) abstract
Antimicrobial beta-defensins are thought to protect epithelial surfaces. Their mobilization in response to inflammation was studied in the rat parotid gland using an ELISA assay. Bacterial lipopolysaccharide (LPS), injected into the parotid duct on one side, induced a marked local inflammatory response in the parotid gland as judged by several fold increases in myeloperoxidase activity and, in histological sections, infiltration of neutrophils. Three hours after the injection, beta-defensin 1 and 3 were increased (by 41% and 15%, respectively, P<0.01) as compared to the contralateral gland. Though still elevated 6h after the injection, the percentage figures for beta-defensin 1 were, at this time, somewhat lower (30%) compared to the situation at 3h, while those for defensin 3 were significantly higher 65% (P<0.01); neither at the early nor at the late time of observation were any changes in the level of beta-defensin 2 observed. The beta-defensins under study were not detected in submandibular and sublingual glands, neither were they detected in the inflamed submandibular gland, showing also here several fold increases in myeloperoxidase activity and, in addition, the presence of inflammatory cells, following ductal injection of LPS towards the gland.
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Almäng, Jan, 1976
(författare)
McDowell's Naturalism
2006
Ingår i: Kvantifikator för en Dag. Essays Dedicated to Dag Westerståhl on his Sixtieth Birthday. - 1652-0459. ; , s. 37-52
Tidskriftsartikel (övrigt vetenskapligt/konstnärligt) abstract
This is an essay on McDowell’s naturalism. It is, pace some commentators, argued that McDowell’s naturalism does not end up in any strange metaphysical positions in the philosophy of mind, because second nature non-reductively supervenes on first nature and have causal powers. Pace certain other commentators, it is also argued that McDowell can be read as drawing a clear line between ethical platonism, and his own naturalized platonism, but only at the cost of landing in standard naturalism.
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Hedner, E., et al.
(författare)
Brominated cyclodipeptides from the marine sponge Geodia barretti as selective 5-HT ligands
2006
Ingår i: Journal of Natural Products. - : American Chemical Society (ACS). - 0163-3864 .- 1520-6025. ; 69:10, s. 1421-1424
Tidskriftsartikel (refereegranskat) abstract
The brominated cyclodipeptides barettin(cyclo[(6-bromo-8-entryptophan) arginine]) and 8,9-dihydrobarettin ( cyclo[(6-bromotryptophan) arginine]) isolated from the marine sponge Geodia barretti have previously been shown to inhibit settlement of barnacle larvae in a dose-dependent manner in concentrations ranging from 0.5 to 25 mu M. To further establish the molecular target and mode of action of these compounds, we investigated their affinity to human serotonin receptors. The tryptophan residue in the barettins resembles that of endogenous serotonin [5-hydroxytryptamine]. A selection of human serotonin receptors, including representatives from all subfamilies (1-7), were transfected into HEK-293 cells. Barettin selectively interacted with the serotonin receptors 5-HT2A, 5-HT2C, and 5-HT4 at concentrations close to that of endogenous serotonin, with the corresponding K-i values being 1.93, 0.34, and 1.91 mu M, respectively. 8,9-Dihydrobarettin interacted exclusively with the 5-HT2C receptor with a K-i value of 4.63 mu M; it failed to show affinity to 5-HT2A and 5-HT4, indicating that the double bond between the tryptophan and arginine residue plays an important role in the interaction with the receptor proteins.
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Jonson, Rebecca, 1976
(författare)
Dialogue Context-Based Reranking of ASR Hypotheses
2006
Ingår i: SLT 2006 : 2006 IEEE ACL Spoken Language Technology Workshop : proceedings : December 10-13, 2006, Aruba Marriott, Palm Beach, Aruba. - 1424408733 ; , s. 174-177
Konferensbidrag (refereegranskat)