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Sökning: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Medicinska och farmaceutiska grundvetenskaper) hsv:(Farmaceutiska vetenskaper) > (2000-2009) > (2008) > Hansson Per

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1.
  • Bysell, Helena, et al. (författare)
  • Transport of poly-L-lysine into oppositely charged poly(acrylic acid) microgels and its effect on gel deswelling.
  • 2008
  • Ingår i: Journal of Colloid and Interface Science. - : Elsevier BV. - 0021-9797 .- 1095-7103. ; 323:1, s. 60-9
  • Tidskriftsartikel (refereegranskat)abstract
    • The interaction between poly-L-lysine (pLys) and oppositely charged poly(acrylic acid) (pAA) microgels (Ø approximately 80-120 microm) was studied by micromanipulator-assisted light microscopy and confocal laser scanning microscopy. The aim of this study was to investigate effects of peptide size, pH, and salt concentration on binding, transport, and distribution of pLys in pAA microgel particles and thereby also to outline the details of the gel deswelling in response to pLys binding and incorporation. Both peptide distribution and gel deswelling kinetics were found to be strongly influenced by the pLys molecular weight, originating partly from limited entry of large peptides into the gel particle core. Also pH was shown to influence both deswelling and pLys incorporation kinetics, with a decreased deswelling rate observed with increasing pH. These effects are determined by a complex interplay between the pH-dependence of both pLys and the gel network, also influencing volume transitions of the latter. Finally, salt concentration was shown to have a significant effect on both gel deswelling rate and pLys transport, with an increased electrolyte concentration resulting in decreased deswelling rate but also in an increased peptide transport rate within the microgel particles.
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2.
  • Nilsson, Peter, et al. (författare)
  • Regular and Irregular Deswelling of Polyacrylate and Hyaluronate Gels Induced by Oppositely Charged Surfactants
  • 2008
  • Ingår i: Journal of Colloid and Interface Science. - : Elsevier BV. - 0021-9797 .- 1095-7103. ; 325:2, s. 316-323
  • Tidskriftsartikel (refereegranskat)abstract
    • The deswelling kinetics of macroscopic polyacrylate (PA) gels in solutions of dodecyltrimethylammonium bromide (C(12)TAB) and cetyltrimethylammonium bromide (C(16)TAB), with and without added sodium bromide, as well as hyaluronate (HA) gels in solutions of cetylpyridinium chloride (CPC) are investigated. Additional data are also provided by small-angle X-ray scattering and microgel experiments. The purpose is to study the deswelling behavior of (1) regularly deswelling gels, for which the deswelling is successfully described using a core/shell model earlier employed for microgels, and (2) irregularly deswelling gels, where the gel turns into a balloon-like structure with a dense outer layer surrounding a liquid-filled core. For regularly deswelling gets, the deswelling of PA/C(12)TAB is found to be controlled by diffusion through both stagnant layer and collapsed surface phase, while for PA/C(16)TAB it is found to be controlled mainly by the latter. The difference in deswelling rate between the two is found to correspond to the difference in surfactant diffusion coefficient in the surface phase. Factors found to promote irregular deswelling, described as balloon formation, are rapid surfactant binding, high bromide and surfactant concentration, longer surfactant chain length, and macroscopic gel size. Scattering data indicating a cubic structure for HA/CPC complexes are reported.
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  • Resultat 1-2 av 2
Typ av publikation
tidskriftsartikel (2)
Typ av innehåll
refereegranskat (2)
Författare/redaktör
Nilsson, Peter (1)
Malmsten, Martin (1)
Bysell, Helena (1)
Lärosäte
Uppsala universitet (2)
Språk
Engelska (2)
Forskningsämne (UKÄ/SCB)
Medicin och hälsovetenskap (2)
År

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