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Search: hsv:(MEDICIN OCH HÄLSOVETENSKAP) hsv:(Medicinska och farmaceutiska grundvetenskaper) hsv:(Farmakologi och toxikologi) > Uppsala University > University of Borås > Oxygen therapy in s...

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Oxygen therapy in suspected acute myocardial infarction

Hofmann, Robin (author)
Karolinska Institutet,Karolinska Institute,Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Div Cardiol, Sjukhusbacken 10, S-11883 Stockholm, Sweden.,Södersjukhuset, Sweden
James, Stefan K, 1964- (author)
Uppsala universitet,Uppsala University,Uppsala University Hospital,Kardiologi,Uppsala kliniska forskningscentrum (UCR),Uppsala University, Sweden
Jernberg, Tomas (author)
Karolinska Institutet,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Cardiol, Stockholm, Sweden.,Danderyd Hospital, Sweden
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Lindahl, Bertil, 1957- (author)
Uppsala universitet,Uppsala University,Kardiologi,Uppsala University, Sweden
Erlinge, David (author)
Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Molekylär kardiologi,Forskargrupper vid Lunds universitet,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Molecular Cardiology,Lund University Research Groups,Lund Univ, Dept Clin Sci, Cardiol, Lund, Sweden.,Lund University, Sweden,Uppsala University
Witt, Nils (author)
Karolinska Institutet,Karolinska Institute,Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Div Cardiol, Sjukhusbacken 10, S-11883 Stockholm, Sweden.,Södersjukhuset, Sweden
Arefalk, Gabriel (author)
Uppsala universitet,Uppsala University,Uppsala University Hospital,Kardiovaskulär epidemiologi,Uppsala University, Sweden,Karolinska Institutet
Frick, Mats (author)
Karolinska Institutet,Karolinska Institute,Soder Sjukhuset, Karolinska Inst, Dept Clin Sci & Educ, Div Cardiol, Sjukhusbacken 10, S-11883 Stockholm, Sweden.,Södersjukhuset, Sweden
Alfredsson, Joakim (author)
Linköpings universitet,Linköping University,Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.;Linkoping Univ, Dept Cardiol, Linkoping, Sweden.,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
Nilsson, Lennart (author)
Linköpings universitet,Linköping University,Linkoping Univ, Dept Med & Hlth Sci, Linkoping, Sweden.;Linkoping Univ, Dept Cardiol, Linkoping, Sweden.,Avdelningen för kardiovaskulär medicin,Medicinska fakulteten,Region Östergötland, Kardiologiska kliniken US
RavnFischer, Annica (author)
Sahlgrenska University Hospital
Omerovic, Elmir (author)
Sahlgrens University Hospital, Sweden,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.
Kellerth, Thomas (author)
Örebro University Hospital, Sweden,Orebro Univ Hosp, Dept Cardiol, Orebro, Sweden.
Sparv, David (author)
Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Lund Univ, Dept Clin Sci, Cardiol, Lund, Sweden.,Lund University, Sweden,Uppsala University
Ekelund, Ulf (author)
Lund University,Lunds universitet,Medicin/akutsjukvård, Lund,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Experimentell kärlforskning,Forskargrupper vid Lunds universitet,Medicine, Lund,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine,Experimental Vascular Research,Lund University Research Groups,Lund Univ, Dept Clin Sci, Emergency Med, Lund, Sweden.,Lund University, Sweden
Linder, Rickard (author)
Karolinska Institutet,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Cardiol, Stockholm, Sweden.,Danderyd Hospital, Sweden
Ekström, Mattias (author)
Karolinska Institutet,Danderyd Hosp, Karolinska Inst, Dept Clin Sci, Cardiol, Stockholm, Sweden.,Danderyd Hospital, Sweden
Lauermann, Jörg (author)
Ryhov County Hospital, Jönköping,Ryhov Hosp, Dept Internal Med, Div Cardiol, Jonkoping, Sweden.,Ryhov Hospital, Sweden
Haaga, Urban (author)
Sahlgrenska University Hospital,Karlstad Central Hospital, Sweden,Karlstad Cent Hosp, Dept Cardiol, Karlstad, Sweden.
Pernow, John (author)
Karolinska Institutet,Karolinska Institute,Karolinska University Hospital, Sweden; Karolinska Institute, Sweden,Karolinska Univ Hosp, Dept Cardiol, Solna, Sweden.;Karolinska Inst, Dept Med, Solna, Sweden.
Östlund, Ollie (author)
Uppsala universitet,Uppsala kliniska forskningscentrum (UCR),Uppsala University, Sweden
Herlitz, Johan, 1949- (author)
Högskolan i Borås,University of Borås,Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.;Univ Boras, Dept Hlth Sci, Boras, Sweden.,Sahlgrens University Hospital, Sweden; University of Boras, Sweden,Akademin för vård, arbetsliv och välfärd
Svensson, Leif (author)
Karolinska Institutet,Karolinska Institute,Soder Sjukhuset, Karolinska Inst, Ctr Resuscitat Sci, Stockholm, Sweden.;Karolinska Inst, Dept Med, Solna, Sweden.,Södersjukhuset, Sweden; Karolinska Institute, Sweden
Yndigegn, Troels (author)
Lund University,Lunds universitet,Kardiologi,Sektion II,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Cardiology,Section II,Department of Clinical Sciences, Lund,Faculty of Medicine
Ravn-Fischer, A (author)
Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.,Sahlgrens University Hospital, Sweden
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MASSACHUSETTS MEDICAL SOC, 2017
2017
English.
In: New England Journal of Medicine. - : MASSACHUSETTS MEDICAL SOC. - 0028-4793 .- 1533-4406. ; 377:13, s. 1240-1249
Related links:
http://dx.doi.org/10...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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  • Journal article (peer-reviewed)
Abstract Subject headings
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  • BACKGROUND: The clinical effect of routine oxygen therapy in patients with suspected acute myocardial infarction who do not have hypoxemia at baseline is uncertain. METHODS: In this registry-based randomized clinical trial, we used nationwide Swedish registries for patient enrollment and data collection. Patients with suspected myocardial infarction and an oxygen saturation of 90% or higher were randomly assigned to receive either supplemental oxygen (6 liters per minute for 6 to 12 hours, delivered through an open face mask) or ambient air. RESULTS: A total of 6629 patients were enrolled. The median duration of oxygen therapy was 11.6 hours, and the median oxygen saturation at the end of the treatment period was 99% among patients assigned to oxygen and 97% among patients assigned to ambient air. Hypoxemia developed in 62 patients (1.9%) in the oxygen group, as compared with 254 patients (7.7%) in the ambient-air group. The median of the highest troponin level during hospitalization was 946.5 ng per liter in the oxygen group and 983.0 ng per liter in the ambient-air group. The primary end point of death from any cause within 1 year after randomization occurred in 5.0% of patients (166 of 3311) assigned to oxygen and in 5.1% of patients (168 of 3318) assigned to ambient air (hazard ratio, 0.97; 95% confidence interval [CI], 0.79 to 1.21; P=0.80). Rehospitalization with myocardial infarction within 1 year occurred in 126 patients (3.8%) assigned to oxygen and in 111 patients (3.3%) assigned to ambient air (hazard ratio, 1.13; 95% CI, 0.88 to 1.46; P=0.33). The results were consistent across all predefined subgroups. CONCLUSIONS: Routine use of supplemental oxygen in patients with suspected myocardial infarction who did not have hypoxemia was not found to reduce 1-year all-cause mortality. (Funded by the Swedish Heart–Lung Foundation and others; DETO2X-AMI ClinicalTrials.gov number, NCT01787110.)

Subject headings

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Kardiologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin (hsv//swe)
MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine (hsv//eng)

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