| 1. |
- Mochalina, Natalia, et al.
(author)
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ABC om Yrsel på akuten
- 2015
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In: Läkartidningen. - 0023-7205. ; 112:9, s. 399-404
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Journal article (peer-reviewed)abstract
- The majority of patients who present to the Emergency Department with vertigo suffer from benign conditions. However, a few percent of these patients have life-threatening conditions, such as a cerebellar stroke. The HINTS clinical decision rule (Head-Impulse test, Nystagmus, Test-of-Skew) allows the physician to identify patients with an acute vestibular syndrome of central origin. HINTS is more sensitive than early magnetic resonance imaging. There is no role for computed tomography in the evaluation of patients with isolated acute vestibular syndrome in the Emergency Department. For patients with benign paroxysmal positional vertigo, simple reposition maneuvers are effective for symptom relief.
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| 2. |
- Marklund, Niklas, et al.
(author)
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Neurokirurgisk omvårdnad
- 2024. - 1
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In: Neurokirurgi. - : Studentlitteratur AB. - 9789144161532 ; , s. 285-296
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Book chapter (pop. science, debate, etc.)
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| 3. |
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| 4. |
- Flisberg, Anders, 1958, et al.
(author)
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EEG and spectral edge frequency : analysis in posthypoxic newborn piglets
- 2010
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In: Neuro - endocrinology letters. - : Brain Research Promotion. - 0172-780X. ; 31:2, s. 181-186
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Journal article (peer-reviewed)abstract
- OBJECTIVE: To evaluate the frequency content of the electroencephalogram (EEG) during recovery after a severe hypoxic insult in newborn piglets. METHODS: EEG was continuously monitored in nine newborn piglets exposed to a severe hypoxic period. Power spectra in five frequency bands were calculated using Fourier transformation. Spectral edge frequency 90 (SEF90) was defined as the frequency below which 90% of the power in the EEG was located. The piglets were divided into two groups; Group 1 represented piglets with some EEG recovery and Group 2 represented piglets without any EEG recovery. RESULTS: The recovery of the EEG in Group 1 had the same time course in all frequency bands. SEF90 indicates recovery earlier than the value of total power. But SEF90 also signals activity in the EEGs that were almost completely suppressed. When SEF90 was calculated during periods of periodic EEG activity during the very early phase of recovery, the values fell within the same range as during the control period. CONCLUSION: Spectral analysis of continuous EEG in newborn piglets exposed to very severe hypoxia showed that no specific frequency band of the EEG preceded the other ones during recovery. The results of the SEF90 measure, demonstrates the need for critical analysis of the raw EEG before any reliable estimation of cerebral function can be made.
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| 5. |
- Rönnbäck, Lars, et al.
(author)
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»Trött i hjärnan« osynligt handikapp som kan ge stora problem: Störd glutamatreglering kan förklara bristande informationsfiltrering
- 2007
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In: Läkartidningen. - 1652-7518 .- 0023-7205. ; 104:14-15, s. 1137-1142
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Journal article (other academic/artistic)abstract
- Cognitive impairment with decreased concentration capacity and mental fatigue makes rehabilitation from a stroke, brain trauma, meningitis or neuroinflammation difficult, and often hampers going back to work. According to our hypothesis, down regulation of the glutamate transport protein GLT-1 in the hippocampus and cerebral cortex is one pathogenic factor underlying mental fatigue. Glutamate is one major signal substance for information intake and processing in the brain. The GLT-1 protein, localised to astrocytes and, upon activation, also microglial cells, is considered to play key roles in the regulation of extracellular glutamate. A slight disturbance of the astroglial regulation of extracellular glutamate could lead to local microglial activation with the production of proinflammatory cytokines, astrocyte swelling, and, due to such swelling, decreased extracellular space. During these conditions, there is a decrease in both the glutamate release and the neuronal transmission. It is proposed that this decreased transmission could be one correlate at the cellular level to the mental exhaustion that the person could experience. Pharmacological treatment, probably with glial cells as targets, could restore dysfunction in the glutamate transmission and make the person less susceptible to pathological mental fatigue.
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| 6. |
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| 7. |
- Agorelius, Johan
(author)
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Development of highly biocompatible neuro-electronic interfaces towards monitoring authentic neuronal signaling in the brain
- 2020
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Doctoral thesis (other academic/artistic)abstract
- Background: To understand how the neuronal circuits in the brain process information there is a need for novelneuro-electronic interfaces that can interact chronically with brain tissue with minimal disturbance of thephysiological conditions in the tissue, in awake and freely moving animals. For this, there is a need for implantableneuro-electronic interfaces that are mechanically compliant with the tissue and that can remain positionally stablewith respect to the neurons, despite the continuous micromotions in the brain. To reach this goal it is alsoimportant to be able to conduct a detailed analysis of the tissue reactions in the juxtapositional tissue around theimplant as well as to incorporate additional strategies such as adding tissue modifying drugs to the implant.Aim: To this end, two different types of implantable neuro-electronic interfaces, addressing the issue ofmechanical compliance with two different approaches, as well as a novel method of sustained drug delivery fromthe neural implants were designed, manufactured and evaluated in vivo.Method: First, arrays of thin gold leads, flexible in 3D, were cut from a 4 μm thin gold sheet, insulated with a thinlayer of Parylene-C (4 μm) and then embedded and structurally locked in a stiff gelatin matrix that dissolves afterimplantation. These arrays were implanted in rats and evaluated electrophysiologically for 3 weeks. Second, anovel tube-like electrode with an opening on the side, comprising a conducting lead embedded in glucoseenveloped by a thin layer of Parylene-C, was developed. After implantation the glucose in this protoelectrodedissolves transforming the protoelectrode into a highly flexible and low density electrode inside the tissue. Suchtube electrodes were implanted in rats and evaluated by means of immunofluorescence microscopy after 6 weeks.Further, minocycline loaded nanoparticles were embedded into a gelatin matrix surrounding neural implants andthe tissue reactions were evaluated in genetically modified mice exhibiting fluorescent microglia by means ofimmunofluorescence microscopy 3 and 7 days after implantation.Results: The developed 3D arrays were found to be implantable with preserved conformation andelectrophysiological recordings showed relatively stable recordings, with spike amplitudes over 400 μV. The tubeelectrode proved to be sliceable in the brain without dislocating, making it possible to analyze the tissue rightoutside the recording site, showing minute glia reactions and no significant loss of neurons as compared tobaseline tissue, even in the inner most zone (0-20 μm). The minocycline loaded nanoparticles where successfullyincorporated in gelatin-coatings of neural implants, and histological analysis showed a significant attenuation ofglia reactions.Conclusion: Two new types of mechanically compliant neuro-electronic interfaces and implantation methods, aswell as a compatible embedding method of local delivery of drug content, has been successfully developed andevaluated, showing very promising biocompatibility and stability in the tissue.
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| 8. |
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| 9. |
- Ahmad, Abdulbaghi, et al.
(author)
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Tiden läkar inte alla sår
- 2006. - 2
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In: Stress, molekyl, individ, organisation och samhälle. - : Liber. ; , s. 128-138
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Book chapter (peer-reviewed)
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| 10. |
- Ahmad, Abdulbaghi, 1951-, et al.
(author)
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Tiden läkar inte alla sår
- 2002. - 1
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In: Stress. - : Liber. - 9147050489
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Book chapter (peer-reviewed)
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