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Acylation of dipyrr...
Acylation of dipyrromethanes at the α and β positions and further development of fluorescent Zn2+ probes
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Tang, Y. (författare)
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Ding, Y. (författare)
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- Li, Xin (författare)
- KTH,Teoretisk kemi och biologi
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- Ågren, Hans (författare)
- KTH,Teoretisk kemi och biologi
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Li, T. (författare)
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Zhang, W. (författare)
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Xie, Y. (författare)
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- Engelska.
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Ingår i: Sensors and actuators. B, Chemical. - : Elsevier BV. - 0925-4005 .- 1873-3077. ; 206, s. 291-302
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- The acylation of 5-aryl dipyrromethanes afforded products with interestingly rich substitution modes, i.e.; α- and β-monoacylated (modes a and b), and α, α′-, α, β′- and β, β′-diacylated (modes c-e). Especially, the β- and β, β′-acylation modes are unprecedented. And most of these products can be synthesized at a gram scale. The anisoyl substituted 5-(4-cyanophenyl) dipyrromethanes (1a-1e) were oxidized with DDQ. Thus, 1a and 1b afforded the corresponding dipyrrins 1a-DPR, and 1b-DPR. More interestingly, the diacylated ones 1c-1e could not be oxidized by DDQ. Instead, 1c-OH-1e-OH were obtained with a hydroxyl group attached to the 5-position. 1a-DPR-1e-OH were further developed as fluorescence turn-on Zn2+ probes. 1d-OH showed the highest sensitivity, with a detection limit of 1.5 × 10-8 M, and it was successfully applied in Zn2+ imaging in Hela cells. Furthermore, single crystals of two Zn2+ complexes were obtained and analyzed by X-ray diffraction.
Ämnesord
- NATURVETENSKAP -- Kemi -- Teoretisk kemi (hsv//swe)
- NATURAL SCIENCES -- Chemical Sciences -- Theoretical Chemistry (hsv//eng)
Nyckelord
- Acylation
- Crystal structure
- Dipyrromethane
- Fluorescence probes
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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