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Maternal, cord, and...
Maternal, cord, and three-year-old child serum thyroid hormone concentrations in the Health Outcomes and Measures of the Environment study
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- Doherty, Brett T (author)
- Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover NH, USA
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- Kosarek, Noelle (author)
- Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover NH, USA
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- Hoofnagle, Andy N (author)
- Department of Laboratory Medicine, University of Washington, Seattle WA, USA
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- Xu, Yingying (author)
- Division of General and Community Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati OH, USA
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- Zoeller, R. Thomas, 1952- (author)
- Örebro universitet,Institutionen för naturvetenskap och teknik,Department of Biology, University of Massachusetts, Amherst MA, USA
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- Yolton, Kimberly (author)
- Division of General and Community Pediatrics, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati College of Medicine, Cincinnati OH, USA
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- Chen, Aimin (author)
- Epidemiology and Biostatistics, Department of Environmental Health, University of Cincinnati College of Medicine, Cincinnati OH, USA
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- Lanphear, Bruce P (author)
- Child and Family Research Institute, BC Children's and Women's Hospital and Faculty of Health Sciences, Simon Fraser University, Vancouver BC, Canada
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- Braun, Joseph M (author)
- Department of Epidemiology, Brown University, Providence RI, USA
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- Romano, Megan E (author)
- Department of Epidemiology, Geisel School of Medicine, Dartmouth College, Hanover NH, USA
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(creator_code:org_t)
- 2020-01-19
- 2020
- English.
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In: Clinical Endocrinology. - : Blackwell Science Ltd.. - 0300-0664 .- 1365-2265. ; 92:4, s. 366-372
- Related links:
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https://www.ncbi.nlm...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- PURPOSE: Maternal thyroid function during pregnancy may influence offspring thyroid function, though relations between maternal and child thyroid function are incompletely understood. We sought to characterize relations between maternal, cord and child thyroid hormone concentrations in a population of mother-child pairs with largely normal thyroid function.METHODS: In a prospective birth cohort, we measured thyroid hormone concentrations in 203 mothers at 16 gestational weeks, 273 newborns and 159 children at 3 years among participants in the Health Outcomes and Measures of the Environment (HOME) Study. We used multivariable linear regression to estimate associations of maternal thyroid hormones during pregnancy with cord serum thyroid hormones and also estimated associations of maternal and cord thyroid hormones with child thyroid-stimulating hormone (TSH).RESULTS: Each doubling of maternal TSH was associated with a 16.4% increase of newborn TSH (95% CI: 3.9%, 30.5%), and each doubling of newborn TSH concentrations was associated with a 10.4% increase in child TSH concentrations at 3 years (95% CI: 0.1%, 21.7%). An interquartile range increase in cord FT4 concentrations was associated with an 11.7% decrease in child TSH concentrations at 3 years (95% CI: -20.2%, -2.3%).CONCLUSIONS: We observed relationships between maternal, newborn and child thyroid hormone concentrations in the HOME Study. Our study contributes to understandings of interindividual variability in thyroid function among mother-child pairs, which may inform future efforts to identify risk factors for thyroid disorders or thyroid-related health outcomes.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
Keyword
- fetal development
- infant
- newborn
- pregnancy
- thyroid diseases
- thyroid hormones
- Enviromental Science
- Miljövetenskap
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Doherty, Brett T
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Kosarek, Noelle
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Hoofnagle, Andy ...
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Xu, Yingying
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Zoeller, R. Thom ...
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Yolton, Kimberly
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show more...
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Chen, Aimin
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Lanphear, Bruce ...
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Braun, Joseph M
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Romano, Megan E
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show less...
- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Endocrinology an ...
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- NATURAL SCIENCES
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NATURAL SCIENCES
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and Earth and Relate ...
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and Environmental Sc ...
- Articles in the publication
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Clinical Endocri ...
- By the university
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Örebro University