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Secondary stimulati...
Secondary stimulation from Bacillus Calmette-Guerin induced macrophages induce nitric oxide independent cell-death in bladder cancer cells
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- Thiel, Tomas (författare)
- Karolinska Institutet
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- Ryk, Charlotta (författare)
- Karolinska Institutet
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- Chatzakos, Vicky (författare)
- Stockholms universitet,Institutionen för genetik, mikrobiologi och toxikologi
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- Grufman, Katarina Hallen (författare)
- Karolinska Institutet
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Bavand-Chobot, Nasrin (författare)
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- Flygare, Jenny (författare)
- Karolinska Institutet
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- Wiklund, N. Peter (författare)
- Karolinska Institutet
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- de Verdier, Petra J. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- Elsevier BV, 2014
- 2014
- Engelska.
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Ingår i: Cancer Letters. - : Elsevier BV. - 0304-3835 .- 1872-7980. ; 348:1-2, s. 119-125
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- The anti-tumour mechanisms following Bacillus Calmette-Guerin (BCG) treatment of bladder-cancer remain largely unknown. Previous studies have shown involvement of nitric-oxide (NO) formation in the BCG-mediated effect. We analyzed the effects of macrophage secreted factors (MSFs) from BCG-stimulated RAW264.7 cells on the bladder-cancer cell line MBT2. Direct treatment with BCG did not induce NO in MBT2-cells whereas supernatant from BCG-stimulated macrophages increased NOS2 mRNA and protein expression, NO concentrations and cell-death. Blocking NO-synthesis with the NOS-inhibitor L-NAME did not affect levels of cell-death suggesting cytotoxic pathways involving other signalling molecules than NO. Several such candidate genes were identified in a microarray.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Cancer och onkologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cancer and Oncology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Mikrobiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Microbiology (hsv//eng)
Nyckelord
- Urinary bladder cancer
- Bacillus Calmette-Guerin
- Nitric oxide
- Nitric oxide synthase
- Cytokines
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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