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Ways and means of e...
Ways and means of eukaryotic mRNA decay
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- Balagopal, Vidya (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Fluch, Lydia (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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- Nissan, Tracy (author)
- Umeå universitet,Institutionen för molekylärbiologi (Medicinska fakulteten)
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(creator_code:org_t)
- New York : Elsevier, 2012
- 2012
- English.
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In: Biochimica et Biophysica Acta (BBA) - Gene Regulatory Mechanisms. - New York : Elsevier. - 1874-9399. ; 1819:6, s. 593-603
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Abstract
Subject headings
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- Messenger RNA degradation is an important point of control for gene expression. Genome-wide studies on mRNA stability have demonstrated its importance in adaptation and stress response. Most of the key players in mRNA decay appear to have been identified. The study of these proteins brings insight into the mechanism of general and specific targeting of transcripts for degradation. Recruitment and assembly of mRNP complexes enhance and bring specificity to mRNA decay. mRNP complexes can form larger structures that have been found to be ubiquitous in nature. Discovery of P-Bodies, an archetype of this sort of aggregates, has generated interest in the question of where mRNA degrades. This is currently an open question under extensive investigation. This review will discuss in detail the recent developments in the regulation of mRNA decay focusing on yeast as a model system.
Subject headings
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
Keyword
- mRNA decay
- P-bodies
- mRNA turnover
- Decapping
Publication and Content Type
- ref (subject category)
- for (subject category)
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