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Reduced levels of I...
Reduced levels of IgM autoantibodies against N-truncated pyroglutamate Abeta in plasma of patients with Alzheimer's disease
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Marcello, Andrea (författare)
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Wirths, Oliver (författare)
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Schneider-Axmann, Thomas (författare)
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- Degerman-Gunnarsson, Malin (författare)
- Uppsala universitet,Geriatrik
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- Lannfelt, Lars (författare)
- Uppsala universitet,Geriatrik
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Bayer, Thomas A (författare)
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(creator_code:org_t)
- Elsevier BV, 2011
- 2011
- Engelska.
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Ingår i: Neurobiology of Aging. - : Elsevier BV. - 0197-4580 .- 1558-1497. ; 32:8, s. 1379-1387
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
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- In the present work, we investigated the level of IgM autoantibodies directed against different Abeta epitopes as potential diagnostic biomarker for Alzheimer's disease (AD). Anti-Abeta autoantibody levels were measured in 75 plasma samples from patients with AD, individuals with mild cognitive impairment (MCI), and healthy age- and sex-matched controls (HC). To validate the presence of anti-Abeta IgMs, pooled plasma samples were subjected to gel-filtration analysis. The mean level of pGluAbeta-IgM (N-terminal truncated starting at position three with pyroglutamate) was significantly decreased in AD patients as compared to HC. In the group of MCI patients there was a significant positive correlation between pGluAbeta-IgM and cognitive decline analyzed by MMSE (rho=0.58, d.f.=13, p=0.022). These observations indicate that the level of IgM autoantibodies against pGluAbeta is a promising plasma biomarker for AD and correlates with the cognitive status of individuals at risk to develop AD.
Nyckelord
- MEDICINE
- MEDICIN
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- ref (ämneskategori)
- art (ämneskategori)
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