I forgot when I lost my grip - Strong associations between cognition and grip strength in level of performance and change across time in relation to impending death

• An association between level of cognitive function and grip strength is well established while evidence for longitudinal associations of change in the two functions is still unclear. We examined associations between cognition and grip strength in levels of performance and in longitudinal change in late life in a population-based sample, aged 80 years and older at baseline, followed until death. The sample consisted of 449 non-demented individuals drawn from the OCTO-twin study. A test battery assessing 6 cognitive domains and grip strength was administered at five occasions with measurements intervals of two years. We fitted time to death bivariate growth curve models, adjusted for age, education and sex which resulted in associations between grip strength and cognition in both levels of performance (across all cognitive domains) and rates of change (in four out of six domains). These results show that cognition and grip strength change conjointly in later life and that the association between cognition and grip strength is stronger prior to death than earlier in life.

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Basic Medicine -- Neurosciences (hsv//eng)

Nyckelord

Cognition

grip strength

later life

terminal decline

Publikations- och innehållstyp

ref (ämneskategori)

art (ämneskategori)