Phenotypic and genetic classification of diabetes

• The historical subclassification of diabetes into predominantly types 1 and 2 is well appreciated to inadequately capture the heterogeneity seen in patient presentations, disease course, response to therapy and disease complications. This review summarises proposed data-driven approaches to further refine diabetes subtypes using clinical phenotypes and/or genetic information. We highlight the benefits as well as the limitations of these subclassification schemas, including practical barriers to their implementation that would need to be overcome before incorporation into clinical practice. Graphical abstract: [Figure not available: see fulltext.].

Ämnesord

MEDICIN OCH HÄLSOVETENSKAP  -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)

MEDICAL AND HEALTH SCIENCES  -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)

Nyckelord

Cluster analysis

Disease subtypes

Genetics

MODY

Personalised medicine

Polygenic score

Precision medicine

Review

Type 1 diabetes

Type 2 diabetes

ANDIS

Publikations- och innehållstyp

for (ämneskategori)

ref (ämneskategori)