Tyck till om SwePub Sök
här!
Search: onr:"swepub:oai:DiVA.org:umu-120636"
> Joshi Shobha >
Daclatasvir combine...
Daclatasvir combined with sofosbuvir or simeprevir in liver transplant recipients with severe recurrent hepatitis C infection
-
Fontana, Robert J. (author)
-
Brown, Robert S., Jr. (author)
-
Moreno-Zamora, Ana (author)
-
show more...
-
Prieto, Martin (author)
-
Joshi, Shobha (author)
-
Londono, Maria-Carlota (author)
-
Herzer, Kerstin (author)
-
Chacko, Kristina R. (author)
-
Stauber, Rudolf E. (author)
-
Knop, Viola (author)
-
Jafri, Syed-Mohammed (author)
-
Castells, Lluis (author)
-
Ferenci, Peter (author)
-
Torti, Carlo (author)
-
Durand, Christine M. (author)
-
Loiacono, Laura (author)
-
Lionetti, Raffaella (author)
-
Bahirwani, Ranjeeta (author)
-
- Weiland, Ola (author)
- Karolinska Institutet
-
Mubarak, Abdullah (author)
-
ElSharkawy, Ahmed M. (author)
-
Stadler, Bernhard (author)
-
Montalbano, Marzia (author)
-
Berg, Christoph (author)
-
Pellicelli, Adriano M. (author)
-
- Stenmark, Stephan (author)
- Umeå universitet,Infektionssjukdomar
-
Vekeman, Francis (author)
-
Ionescu-Ittu, Raluca (author)
-
Emond, Bruno (author)
-
Reddy, K. Rajender (author)
-
show less...
-
(creator_code:org_t)
- 2016-03-28
- 2016
- English.
-
In: Liver transplantation. - : Ovid Technologies (Wolters Kluwer Health). - 1527-6465 .- 1527-6473. ; 22:4, s. 446-458
- Related links:
-
https://aasldpubs.on...
-
show more...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
http://kipublication...
-
show less...
Abstract
Subject headings
Close
- Daclatasvir (DCV) is a potent, pangenotypic nonstructural protein 5A inhibitor with demonstrated antiviral efficacy when combined with sofosbuvir (SOF) or simeprevir (SMV) with or without ribavirin (RBV) in patients with chronic hepatitis C virus (HCV) infection. Herein, we report efficacy and safety data for DCV-based all-oral antiviral therapy in liver transplantation (LT) recipients with severe recurrent HCV. DCV at 60mg/day was administered for up to 24 weeks as part of a compassionate use protocol. The study included 97 LT recipients with a mean age of 59.3 +/- 8.2 years; 93% had genotype 1 HCV and 31% had biopsy-proven cirrhosis between the time of LT and the initiation of DCV. The mean Model for End-Stage Liver Disease (MELD) score was 13.0 +/- 6.0, and the proportion with Child-Turcotte-Pugh (CTP) A/B/C was 51%/31%/12%, respectively. Mean HCV RNA at DCV initiation was 14.3x6 log(10) IU/mL, and 37% had severe cholestatic HCV infection. Antiviral regimens were selected by the local investigator and included DCV+SOF (n=77), DCV+SMV (n=18), and DCV+SMV+SOF (n=2); 35% overall received RBV. At the end of treatment (EOT) and 12 weeks after EOT, 88 (91%) and 84 (87%) patients, respectively, were HCV RNA negative or had levels <43 IU/mL. CTP and MELD scores significantly improved between DCV-based treatment initiation and last contact. Three virological breakthroughs and 2 relapses occurred in patients treated with DCV+SMV with or without RBV. None of the 8 patient deaths (6 during and 2 after therapy) were attributed to therapy. In conclusion, DCV-based all-oral antiviral therapy was well tolerated and resulted in a high sustained virological response in LT recipients with severe recurrent HCV infection. Most treated patients experienced stabilization or improvement in their clinical status.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Fontana, Robert ...
-
Brown, Robert S. ...
-
Moreno-Zamora, A ...
-
Prieto, Martin
-
Joshi, Shobha
-
Londono, Maria-C ...
-
show more...
-
Herzer, Kerstin
-
Chacko, Kristina ...
-
Stauber, Rudolf ...
-
Knop, Viola
-
Jafri, Syed-Moha ...
-
Castells, Lluis
-
Ferenci, Peter
-
Torti, Carlo
-
Durand, Christin ...
-
Loiacono, Laura
-
Lionetti, Raffae ...
-
Bahirwani, Ranje ...
-
Weiland, Ola
-
Mubarak, Abdulla ...
-
ElSharkawy, Ahme ...
-
Stadler, Bernhar ...
-
Montalbano, Marz ...
-
Berg, Christoph
-
Pellicelli, Adri ...
-
Stenmark, Stepha ...
-
Vekeman, Francis
-
Ionescu-Ittu, Ra ...
-
Emond, Bruno
-
Reddy, K. Rajend ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Infectious Medic ...
- Articles in the publication
-
Liver transplant ...
- By the university
-
Umeå University
-
Karolinska Institutet