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Intakes of vitamins...
Intakes of vitamins A, C, and E and use of multiple vitamin supplements and risk of colon cancer : a pooled analysis of prospective cohort studies
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Park, Yikyung (author)
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Spiegelman, Donna (author)
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Hunter, David J. (author)
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Albanes, Demetrius (author)
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- Bergkvist, Leif (author)
- Uppsala universitet,Centrum för klinisk forskning, Västerås
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Buring, Julie E. (author)
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Freudenheim, Jo L. (author)
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Giovannucci, Edward (author)
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Goldbohm, R. Alexandra (author)
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Harnack, Lisa (author)
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Kato, Ikuko (author)
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Krogh, Vittorio (author)
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Leitzmann, Michael F. (author)
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Limburg, Paul J. (author)
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Marshall, James R. (author)
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McCullough, Marjorie L. (author)
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Miller, Anthony B. (author)
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Rohan, Thomas E. (author)
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Schatzkin, Arthur (author)
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Shore, Roy (author)
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Sieri, Sabina (author)
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Stampfer, Meir J. (author)
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Virtamo, Jarmo (author)
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Weijenberg, Matty (author)
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Willett, Walter C. (author)
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- Wolk, Alicja (author)
- Karolinska Institutet
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Zhang, Shumin M. (author)
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Smith-Warner, Stephanie A. (author)
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(creator_code:org_t)
- 2010-09-05
- 2010
- English.
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In: Cancer Causes and Control. - : Springer Science and Business Media LLC. - 0957-5243 .- 1573-7225. ; 21:11, s. 1745-1757
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https://europepmc.or...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Subject headings
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- To evaluate the associations between intakes of vitamins A, C, and E and risk of colon cancer. Using the primary data from 13 cohort studies, we estimated study- and sex-specific relative risks (RR) with Cox proportional hazards models and subsequently pooled RRs using a random effects model. Among 676,141 men and women, 5,454 colon cancer cases were identified (7-20 years of follow-up across studies). Vitamin A, C, and E intakes from food only were not associated with colon cancer risk. For intakes from food and supplements (total), the pooled multivariate RRs (95% CI) were 0.88 (0.76-1.02, > 4,000 vs. a parts per thousand currency sign1,000 mu g/day) for vitamin A, 0.81 (0.71-0.92, > 600 vs. a parts per thousand currency sign100 mg/day) for vitamin C, and 0.78 (0.66-0.92, > 200 vs. a parts per thousand currency sign6 mg/day) for vitamin E. Adjustment for total folate intake attenuated these associations, but the inverse associations with vitamins C and E remained significant. Multivitamin use was significantly inversely associated with colon cancer risk (RR = 0.88, 95% CI: 0.81-0.96). Modest inverse associations with vitamin C and E intakes may be due to high correlations with folate intake, which had a similar inverse association with colon cancer. An inverse association with multivitamin use, a major source of folate and other vitamins, deserves further study.
Keyword
- Vitamin A
- Vitamin C
- Vitamin E
- Multivitamin
- Colon cancer
- Cohort study
- Pooled analysis
- MEDICINE
- MEDICIN
Publication and Content Type
- ref (subject category)
- art (subject category)
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- By the author/editor
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Park, Yikyung
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Spiegelman, Donn ...
-
Hunter, David J.
-
Albanes, Demetri ...
-
Bergkvist, Leif
-
Buring, Julie E.
-
show more...
-
Freudenheim, Jo ...
-
Giovannucci, Edw ...
-
Goldbohm, R. Ale ...
-
Harnack, Lisa
-
Kato, Ikuko
-
Krogh, Vittorio
-
Leitzmann, Micha ...
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Limburg, Paul J.
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Marshall, James ...
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McCullough, Marj ...
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Miller, Anthony ...
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Rohan, Thomas E.
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Schatzkin, Arthu ...
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Shore, Roy
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Sieri, Sabina
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Stampfer, Meir J ...
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Virtamo, Jarmo
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Weijenberg, Matt ...
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Willett, Walter ...
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Wolk, Alicja
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Zhang, Shumin M.
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Smith-Warner, St ...
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show less...
- Articles in the publication
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Cancer Causes an ...
- By the university
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Uppsala University
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Karolinska Institutet