Search: onr:"swepub:oai:gup.ub.gu.se/268535"
> Papakokkinou Eleni >
Worse Health-Relate...
Worse Health-Related Quality of Life at long-term follow-up in patients with Cushing's disease than patients with cortisol producing adenoma. Data from the ERCUSYN
-
Valassi, E. (author)
-
Feelders, R. (author)
-
Maiter, D. (author)
-
show more...
-
Chanson, P. (author)
-
Yaneva, M. (author)
-
Reincke, M. (author)
-
Krsek, M. (author)
-
Toth, M. (author)
-
Webb, S. M. (author)
-
Santos, A. (author)
-
Paiva, I. (author)
-
Komerdus, I. (author)
-
Droste, M. (author)
-
Tabarin, A. (author)
-
Strasburger, C. J. (author)
-
Franz, H. (author)
-
Trainer, P. J. (author)
-
Newell-Price, J. (author)
-
Wass, J. A. H. (author)
-
- Papakokkinou, Eleni (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
-
- Ragnarsson, Oskar, 1971 (author)
- Gothenburg University,Göteborgs universitet,Institutionen för medicin,Institute of Medicine
-
show less...
-
(creator_code:org_t)
- 2018-04-16
- 2018
- English.
-
In: Clinical Endocrinology. - : Wiley. - 0300-0664. ; 88:6, s. 787-798
- Related links:
-
https://gup.ub.gu.se...
-
show more...
-
https://doi.org/10.1...
-
show less...
Abstract
Subject headings
Close
- ObjectiveHypercortisolism in Cushing's syndrome (CS) is associated with impaired health-related quality of life (HRQoL), which may persist despite remission. We used the data entered into the European Registry on Cushing's syndrome (ERCUSYN) to evaluate if patients with CS of pituitary origin (PIT-CS) have worse HRQoL, both before and after treatment than patients with adrenal causes (ADR-CS). MethodsData from 595 patients (492 women; 83%) who completed the CushingQoL and/or EQ-5D questionnaires at baseline and/or following treatment were analysed. ResultsAt baseline, HRQoL did not differ between PIT-CS (n=293) and ADR-CS (n=120) on both EuroQoL and CushingQoL. Total CushingQoL score in PIT-CS and ADR-CS was 4118 and 44 +/- 20, respectively (P=.7). At long-time follow-up (>1year after treatment) total CushingQoL score was however lower in PIT-CS than ADR-CS (56 +/- 20 vs 62 +/- 23; P=.045). In a regression analysis, after adjustment for baseline age, gender, remission status, duration of active CS, glucocorticoid dependency and follow-up time, no association was observed between aetiology and HRQoL. Remission was associated with better total CushingQoL score (P<.001), and older age at diagnosis with worse total score (P=.01). Depression at diagnosis was associated with worse total CushingQoL score at the last follow-up (P<.001). ConclusionPIT-CS patients had poorer HRQoL than ADR-CS at long-term follow-up, despite similar baseline scoring. After adjusting for remission status, no interaetiology differences in HRQoL scoring were found. Age and presence of depression at diagnosis of CS may be potential predictors of worse HRQoL regardless of CS aetiology.
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Endokrinologi och diabetes (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Endocrinology and Diabetes (hsv//eng)
Keyword
- Cushing's syndrome
- ERCUSYN
- health-related quality of life
- clinical-practice
- remission
- adrenalectomy
- questionnaire
- hypercortisolism
- psychopathology
- impairments
- management
- brain
- cure
- Endocrinology & Metabolism
Publication and Content Type
- ref (subject category)
- art (subject category)
Find in a library
To the university's database
- By the author/editor
-
Valassi, E.
-
Feelders, R.
-
Maiter, D.
-
Chanson, P.
-
Yaneva, M.
-
Reincke, M.
-
show more...
-
Krsek, M.
-
Toth, M.
-
Webb, S. M.
-
Santos, A.
-
Paiva, I.
-
Komerdus, I.
-
Droste, M.
-
Tabarin, A.
-
Strasburger, C. ...
-
Franz, H.
-
Trainer, P. J.
-
Newell-Price, J.
-
Wass, J. A. H.
-
Papakokkinou, El ...
-
Ragnarsson, Oska ...
-
show less...
- About the subject
-
- MEDICAL AND HEALTH SCIENCES
-
MEDICAL AND HEAL ...
-
and Clinical Medicin ...
-
and Endocrinology an ...
- Articles in the publication
-
Clinical Endocri ...
- By the university
-
University of Gothenburg