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  • Su, Ting, et al. (author)
  • The force-sensing peptide VemP employs extreme compaction and secondary structure formation to induce ribosomal stalling
  • 2017
  • In: eLIFE. - 2050-084X. ; 6
  • Journal article (peer-reviewed)abstract
    • Interaction between the nascent polypeptide chain and the ribosomal exit tunnel can modulate the rate of translation and induce translational arrest to regulate expression of downstream genes. The ribosomal tunnel also provides a protected environment for initial protein folding events. Here, we present a 2.9 angstrom cryo-electron microscopy structure of a ribosome stalled during translation of the extremely compacted VemP nascent chain. The nascent chain forms two a-helices connected by an a-turn and a loop, enabling a total of 37 amino acids to be observed within the first 50-55 angstrom of the exit tunnel. The structure reveals how a-helix formation directly within the peptidyltransferase center of the ribosome interferes with aminoacyl-tRNA accommodation, suggesting that during canonical translation, a major role of the exit tunnel is to prevent excessive secondary structure formation that can interfere with the peptidyltransferase activity of the ribosome.
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Type of publication
journal article (1)
Type of content
peer-reviewed (1)
Author/Editor
Wilson, Daniel N. (1)
von Heijne, Gunnar (1)
Sohmen, Daniel (1)
Berninghausen, Otto (1)
Beckmann, Roland (1)
Hedman, Rickard (1)
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Cheng, Jingdong (1)
Su, Ting (1)
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University
Stockholm University (1)
Language
English (1)
Research subject (UKÄ/SCB)
Natural sciences (1)
Year
2017 (1)

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