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Alpha-Synuclein Rep...
Alpha-Synuclein Repeat Variants and Survival in Parkinson's Disease
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Chung, Sun Ju (author)
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Biernacka, Joanna M. (author)
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Armasu, Sebastian M. (author)
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Anderson, Kari (author)
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Frigerio, Roberta (author)
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Aasly, Jan O. (author)
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Annesi, Grazia (author)
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Bentivoglio, Anna Rita (author)
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Brighina, Laura (author)
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Chartier-Harlin, Marie-Christine (author)
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Goldwurm, Stefano (author)
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Hadjigeorgiou, Georgios (author)
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Jasinska-Myga, Barbara (author)
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Jeon, Beom Seok (author)
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Kim, Yun Joong (author)
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Krueger, Rejko (author)
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Lesage, Suzanne (author)
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Markopoulou, Katerina (author)
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Mellick, George (author)
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Morrison, Karen E. (author)
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- Puschmann, Andreas (author)
- Lund University,Lunds universitet,Neurologi, Lund,Sektion IV,Institutionen för kliniska vetenskaper, Lund,Medicinska fakulteten,Neurology, Lund,Section IV,Department of Clinical Sciences, Lund,Faculty of Medicine
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Tan, Eng-King (author)
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Crosiers, David (author)
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Theuns, Jessie (author)
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Van Broeckhoven, Christine (author)
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- Wirdefeldt, Karin (author)
- Karolinska Institutet
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Wszolek, Zbigniew K. (author)
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Elbaz, Alexis (author)
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Maraganore, Demetrius M. (author)
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(creator_code:org_t)
- 2014-02-27
- 2014
- English.
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In: Movement Disorders. - : Wiley. - 0885-3185. ; 29:8, s. 1053-1057
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Abstract
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- Objectives: To determine whether alpha-synuclein dinucleotide repeat (REP1) genotypes are associated with survival in Parkinson's disease (PD). Methods: Investigators from the Genetic Epidemiology of Parkinson's Disease Consortium provided REP1 genotypes and baseline and follow-up clinical data for cases. The primary outcome was time to death. Cox proportional hazards regression models were used to assess the association of REP1 genotypes with survival. Results: Twenty-one sites contributed data for 6,154 cases. There was no significant association between alpha-synuclein REP1 genotypes and survival in PD. However, there was a significant association between REP1 genotypes and age at onset of PD (hazard ratio: 1.06; 95% confidence interval: 1.01-1.10; P value = 0.01). Conclusions: In our large consortium study, alpha-synuclein REP1 genotypes were not associated with survival in PD. Further studies of alpha-synuclein's role in disease progression and long-term outcomes are needed. (C) 2014 International Parkinson and Movement Disorder Society
Subject headings
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Keyword
- Parkinson's disease
- alpha-synuclein
- gene
- survival
- association
Publication and Content Type
- art (subject category)
- ref (subject category)
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- By the author/editor
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Chung, Sun Ju
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Biernacka, Joann ...
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Armasu, Sebastia ...
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Anderson, Kari
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Frigerio, Robert ...
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Aasly, Jan O.
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show more...
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Annesi, Grazia
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Bentivoglio, Ann ...
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Brighina, Laura
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Chartier-Harlin, ...
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Goldwurm, Stefan ...
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Hadjigeorgiou, G ...
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Jasinska-Myga, B ...
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Jeon, Beom Seok
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Kim, Yun Joong
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Krueger, Rejko
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Lesage, Suzanne
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Markopoulou, Kat ...
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Mellick, George
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Morrison, Karen ...
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Puschmann, Andre ...
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Tan, Eng-King
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Crosiers, David
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Theuns, Jessie
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Van Broeckhoven, ...
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Wirdefeldt, Kari ...
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Wszolek, Zbignie ...
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Elbaz, Alexis
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Maraganore, Deme ...
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- About the subject
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- MEDICAL AND HEALTH SCIENCES
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MEDICAL AND HEAL ...
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and Clinical Medicin ...
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and Neurology
- Articles in the publication
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Movement Disorde ...
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Movement disorde ...
- By the university
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Lund University
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Karolinska Institutet