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Sökning: tom karlsson > (2015-2019)

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  • Föregående 123[4]
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  • Kilpeläinen, Tuomas O, et al. (författare)
  • Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels.
  • 2016
  • Ingår i: Nature Communications. - : Nature Publishing Group. - 2041-1723. ; 7
  • Tidskriftsartikel (refereegranskat)abstract
    • Leptin is an adipocyte-secreted hormone, the circulating levels of which correlate closely with overall adiposity. Although rare mutations in the leptin (LEP) gene are well known to cause leptin deficiency and severe obesity, no common loci regulating circulating leptin levels have been uncovered. Therefore, we performed a genome-wide association study (GWAS) of circulating leptin levels from 32,161 individuals and followed up loci reaching P<10(-6) in 19,979 additional individuals. We identify five loci robustly associated (P<5 × 10(-8)) with leptin levels in/near LEP, SLC32A1, GCKR, CCNL1 and FTO. Although the association of the FTO obesity locus with leptin levels is abolished by adjustment for BMI, associations of the four other loci are independent of adiposity. The GCKR locus was found associated with multiple metabolic traits in previous GWAS and the CCNL1 locus with birth weight. Knockdown experiments in mouse adipose tissue explants show convincing evidence for adipogenin, a regulator of adipocyte differentiation, as the novel causal gene in the SLC32A1 locus influencing leptin levels. Our findings provide novel insights into the regulation of leptin production by adipose tissue and open new avenues for examining the influence of variation in leptin levels on adiposity and metabolic health.
  • Nightingale, A. J., et al. (författare)
  • Background and history of sustainability
  • 2019
  • Ingår i: Environment and Sustainability in a Globalizing World. Andrea J. Nightingale (red.). - New York : Routledge. - 9781317501831 ; , s. 13-34
  • Bokkapitel (övrigt vetenskapligt)abstract
    • This chapter explores how the idea of sustainability has changed over time and within different regions. The expansion of the Industrial Revolution brought environmental concerns firmly onto the political agenda and established many of the environmental—social—economic relations that continue to shape sustainability challenges. The Industrial Revolution along with colonialism brought about widespread changes in economies and environments upon which the emerging global economy depended. Steady state is used in the environmental field to indicate an ecosystem, organism, or place that is in balance. While Thomas R. Malthus maintained that population growth would eventually lead to a crisis of resources, he simultaneously believed that technological progress could postpone the inevitable need to reduce demands on resource. Neo-Malthusianism refers to a line of thought advocating population control to ensure resource availability for current and future populations. Ideas of limits to economic growth, the need for moderating human exploitation of resources, and the desirability of steady states thus have a long history. © 2019 Taylor & Francis.
  • Nightingale, A. J., et al. (författare)
  • Enacting sustainability
  • 2019
  • Ingår i: Environment and Sustainability in a Globalizing World. Andrea J. Nightingale (red.). - New York : Routledge. - 9781317501831 ; , s. 56-81
  • Bokkapitel (övrigt vetenskapligt)abstract
    • This chapter looks at the ways that narratives of sustainability have been put into practice. It deals with the idea of measuring sustainability, and examines how approaches based in the biophysical sciences may differ from those in the social sciences. Measuring sustainability and sustainable development poses a number of problems, not least of which are availability of data. Many indicators put ecology at the core of sustainability, assuming that ecological sustainability is a prerequisite for social and economic sustainability. An ecological footprint represents the amount of biologically productive land and sea area necessary to supply the resources and energy a given human population consumes and needs to dispose of its waste. Ecological science has been primarily underpinned by the idea of stability at least since Frederic Clements’ seminal text on climax vegetation in 1936. The idea of planetary boundaries has captured the imagination of sustainability communities and has helped to increase awareness of sustainability issues. © 2019 Taylor & Francis.
  • Nightingale, A. J., et al. (författare)
  • Narratives of sustainability key concepts and issues
  • 2019
  • Ingår i: Environment and Sustainability in a Globalizing World. Andrea J. Nightingale (red.). - New York : Routledge. - 9781317501831 ; , s. 35-55
  • Bokkapitel (övrigt vetenskapligt)abstract
    • This chapter reviews some of the key concepts and issues in sustainability debates in order to better understand how sustainability can be invoked for a wide range of purposes. By scrutinizing the narratives of environment and society that underpin sustainability, a wide range of conflicting conceptualizations becomes evident. The chapter deals with a discussion about the contrasting conceptualizations that underpin different narratives of sustainability. Social movements seeking to articulate competing visions of sustainability often draw upon the historically rooted value systems and ways of conceptualizing socionatures to move beyond anthropocentrism and ecocentrism. Linking society and environment ontologically through a socionatures conceptualization recognizes that entities like forests, grasslands, human bodies, even the atmosphere, are socio-natural entities. Most sustainability narratives are predicated upon some separation of society from environment. Two other narratives that are particularly important for understanding sustainability are anthropocentrism and ecocentrism. Anthropocentrism advocates often promote technical and managerial approaches to solve environmental crises. © 2019 Taylor & Francis.
  • Santti, Kirsi, et al. (författare)
  • High cyclin A expression, but not Ki67, is associated with early recurrence in desmoid tumors
  • 2018
  • Ingår i: Journal of Surgical Oncology. - : Wiley-Interscience Publishers. - 0022-4790 .- 1096-9098. ; 118:1, s. 192-198
  • Tidskriftsartikel (refereegranskat)abstract
    • BACKGROUND AND OBJECTIVES: Desmoid tumors are soft-tissue tumors originating from myofibroblasts with a tendency to recur after surgery. High expression of proliferation markers is associated with shortened progression-free and/or overall survival in many neoplasms, including soft-tissue sarcomas. We investigated the prognostic role of cyclin A and Ki67 in desmoid tumors by immunohistochemistry.METHODS: The study included 76 patients with desmoid tumor operated at Helsinki University Hospital between 1987 and 2011. A tissue micro array (TMA) was constructed and the TMA sections were immunostained with cyclin A and Ki67 antibodies. A computer-assisted image analysis was performed.RESULTS: Cyclin A expression was evaluable in 74 and Ki67 in 70 patients. Cyclin A immunopositivity varied from 0% to 9.9%, with a mean of 1.9%. Cyclin A expression correlated significantly with Ki67. Cyclin A expression was associated with recurrence-free survival (HR 1.9, 95% CI = 1.1-3.2, P = .02), as were positive margin (HR 6.0, 95% CI = 1.6-22.5, P = .008) and extremity location (HR 5.3, 95% CI = 1.7-16.8, P = 0.005). Ki67 immunopositivity varied from 0.33% to 13.8%, with a mean of 4.6%, but had no significant prognostic impact (HR 1.1, P = .2).CONCLUSIONS: Our study indicates that cyclin A may be a new prognostic biomarker in surgically treated desmoid tumors.
  • Sandgren, Henrik, 1984, et al. (författare)
  • Avsnitt 1: Varför en podd om offentlig förvaltning
  • 2018
  • Ingår i: Förvaltningspodden - Förvaltningshögskolans poddradio. ; :1
  • Annan publikation (övrigt vetenskapligt)abstract
    • December 2018. Vad är offentlig förvaltning, och varför är det intressant? Medverkande: Tom S. Karlsson, Gustaf Kastberg, Henrik Sandgren och Oskar Svärd.
  • Sandgren, Henrik, 1984 (författare)
  • Avsnitt 6: New Public Management – Del 1
  • 2019
  • Ingår i: Förvaltningspodden - Förvaltningshögskolans poddradio. - Göteborg : Förvaltningshögskolan, Göteborgs universitet. ; :6
  • Annan publikation (övrigt vetenskapligt)abstract
    • September 2019. Få saker har fått utstå så mycket kritik, samtidigt som det är en så integrerad del i vårt samhälle, som New Public Management (NPM). Men vad är NPM för något egentligen, och hur har det kommit hit? Medverkande: Tom Karlsson, Gustaf Kastberg och Henrik Sandgren.
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  • Föregående 123[4]
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Karlsson, Tom, 1979 (20)
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Sprei, Frances, 1977 (3)
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