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Träfflista för sökning "WFRF:(Muller E) ;srt2:(1995-1999)"

Sökning: WFRF:(Muller E) > (1995-1999)

  • Resultat 1-10 av 11
  • [1]2Nästa
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  • Muller, J, et al. (författare)
  • Management of males with 45,X/46,XY gonadal dysgenesis
  • 1999
  • Ingår i: Hormone research. - : S. Karger AG. - 0301-0163. ; 52:1, s. 11-14
  • Tidskriftsartikel (refereegranskat)abstract
    • Males with the 45,X/46,XY karyotype and malformations of the external genitalia carry an increased risk of developing germ cell neoplasia of the gonads. We have studied gonadal tissue from 10 individuals, 0.3–17 years of age, with a male phenotype and either hypospadias and/or cryptorchidism. Four patients, 0.3–15 years of age, had carcinoma in situ, 1 boy had Sertoli-cell-only pattern and the remainder prepubertal histology. Gonadoblastoma or invasive carcinoma was not found. On the basis of our current knowledge we propose a strategy for management and follow-up of these boys in order to detect possible premalignant histological changes early and prevent development of a gonadal tumour.
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  • Olofsson, A M, et al. (författare)
  • Heparin-binding protein targeted to mitochondrial compartments protects endothelial cells from apoptosis
  • 1999
  • Ingår i: Journal of Clinical Investigation. - 0021-9738. ; 104:7, s. 885-894
  • Tidskriftsartikel (refereegranskat)abstract
    • Neutrophil-borne heparin-binding protein (HBP) is a multifunctional protein involved in the progression of inflammation. HBP is stored in neutrophil granules and released upon stimulation of the cells in proximity to endothelial cells. HBP affects endothelial cells in multiple ways; however, the molecular and cellular mechanisms underlying the interaction of HBP with these cells are unknown. Affinity isolation and enzymatic degradation demonstrated that HBP released from human neutrophils binds to endothelial cell-surface proteoglycans, such as syndecans and glypican. Flow cytometry indicated that a significant fraction of proteoglycan-bound HBP is taken up by the endothelial cells, and we used radiolabeled HBP to determine the internalization rate of surface-bound HBP. Confocal and electron microscopy revealed that internalized HBP is targeted to perinuclear compartments of endothelial cells, where it colocalizes with mitochondria. Western blotting of isolated mitochondria from HBP-treated endothelial cells showed that HBP is present in 2 forms - 28 and 22 kDa. Internalized HBP markedly reduced growth factor deprivation-induced caspase-3 activation and protected endothelial cells from apoptosis, suggesting that uptake and intracellular routing of exogenous HBP to mitochondria contributes to the sustained viability of endothelial cells in the context of locally activated neutrophils.
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  • de Zegher, F, et al. (författare)
  • Androgens and fetal growth
  • 1998
  • Ingår i: Hormone research. - : S. Karger AG. - 0301-0163. ; 50:4, s. 243-244
  • Tidskriftsartikel (refereegranskat)abstract
    • Boys are heavier than girls at term birth. Children with a 46,XY karyotype and androgen insensitivity syndrome (clinically complete form and/or proven mutations in the androgen receptor gene) were found to have a birth weight comparable to that of girls. These findings support the hypothesis that the difference in birth weight between boys and girls is generated by androgen action.
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  • Engelmann U. Schröter A, Baur U, Werner O, Göransson B, Borälv E, Schwab M, Müller H, Bahner M, Meinzer HP. (författare)
  • Experiences with the German teleradiology system MEDICUS
  • 1998
  • Ingår i: Yearbook of Medical Informatics '98 - Health Informatics and the Internet. - : Stuttgart: Schattauer. ; , s. 199-207
  • Konferensbidrag (övrigt vetenskapligt/konstnärligt)
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  • Resultat 1-10 av 11
  • [1]2Nästa

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