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Genetic dissection ...
Genetic dissection of complex traits / edited by D.C. Rao, C. Charles Gu.
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Rao, D. C. (Dabeeru C.) (redaktör/utgivare)
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Gu, C. Charles (redaktör/utgivare)
- ISBN 9780080569116
- 2. ed.
- London ; Academic Press, 2008
- Engelska elektronisk resurs (xxvii, 760 s.
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Serie: Advances in genetics (Online), 0065-2660 ; 60
- Relaterad länk:
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http://www.sciencedi... (Table of contents)
Innehållsförteckning
Abstract
Ämnesord
Stäng
- 1. An overview of the genetic dissection of complex traits / D. C. Rao -- 2. Familial resemblance and heritability / Treva K. Rice -- 3. Linkage and association: basic concepts / Ingrid B. Borecki and Michael A. Province -- 4. Definition of phenotype / 5. Genotyping platforms for mass-throughput genotyping with SNPs, including human genome-wide scans / Karen Maresso and Ulrich Broeckel -- 6. Genotyping errors and their impact on genetic analysis / Michael B. Miller, Karen Schwander, and D. C. Rhao -- 7. Model-based methods for linkage analysis / John P. Rice, Nancy L. Saccone, and Jonathan Corbett -- 8. Contemporary model-free methods for linkage analysis / Laura Almasy and John Blangero -- 9. DNA sequence-based phenotypic association analysis / Nicholas J. Schork, Jennifer Wessel, and Nathalie Malo --.
- 10. Family-based methods for linkage and association analysis / Nan M. Laird and Christoph Lange -- 11. Searching for additional disease loci in a genomic region / Glenys Thomson, Lisa F. Barcellos, and Ana M. Valdes -- 12. Methods for handling multiple testing / Treva K. Rice, Nicholas J. Schork, and D. C. Rao -- 13. Meta-analysis methods / Thomas A. Trikalinos, Georgia Salanti, Eias Zintzaras, and John P. A. Ioannidis -- 14. Haplotype-association analysis / Nianjun Liu, Kui Zhang, and Hongyu Zhao -- 15. Characterization LD structures and the utility of HapMap in genetic association studies / C. Charles Gu, Kai Yu, and D. C. Rao -- 16. Associations among multiple markers and complex disease: models, algorithms, and applications / Themistocles L. Assimes, Adam B. Olshen, Balasubramanian Narasimhan, and Richard A. Olshen --.
- 17. Study designs for genome-wide association studies / Peter Kraft and David G. Cox -- 18. Ethical, legal, and social implications of biobanks for genetics research / Susanne B. Haga and Laura M. Beskow -- 19. Admixture mapping and the role of population structure for localizing disease genes / Xiaofeng Zhu, Hua Tang, and Neil Risch -- 20. Integrating global gene expression analysis and genetics / Clarles R. Farber and Aldons J. Lusis -- 21. A systems biology approach to drug discovery / Jun Zhu, Bin Zhang, and Eric E. Schadt -- 22. The promise of composite likelihood methods for addressing computationally intensive challenges / Na Li -- 23 Comparative genomics for detecting human disease genes / Carol Moreno, Jozef Lazar, Howard J. Jacob, and Anne E. Kwitek -- 24. From genetics to mechanism of disease liability / Andreas Rohrwasser, Paul Lott, Robert B. Weiss, and Jean-Marc Lalouel -- 25. Into the Post-HapMap era / Newton E. Morton.
No summary available
Ämnesord
- Medical genetics (LCSH)
- Genetic epidemiology (LCSH)
- Syndromes -- Genetic aspects (LCSH)
Publikations- och innehållstyp
- QH431.A1 (LCC)
- RB155 (NAL)
- 616.042 (DDC)
- Vaa (kssb/8 (machine generated))
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