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LIBRIS Formathandbok  (Information om MARC21)
FältnamnIndikatorerMetadata
00005819naa a22010333a 4500
00119660674
003SE-LIBR
00520160906175512.0
007cr||||||||||||
008160906s2016 sw |||| o |||| ||eng c
0247 a http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-1206292 uri
0247 a urn:nbn:se:umu:diva-1206292 urn
0247 a 10.1186/s12916-016-0607-52 doi
040 a S
0410 a eng
042 9 EPLK
1001 a Ordóñez-Mena, José Manuel4 aut
2451 0a Quantification of the smoking-associated cancer risk with rate advancement periodsh [Elektronisk resurs]b meta-analysis of individual participant data from cohorts of the CHANCES consortium
260 c 2016
500 a Published
5060 a gratis
520 a Background: Smoking is the most important individual risk factor for many cancer sites but its association with breast and prostate cancer is not entirely clear. Rate advancement periods (RAPs) may enhance communication of smoking related risk to the general population. Thus, we estimated RAPs for the association of smoking exposure (smoking status, time since smoking cessation, smoking intensity, and duration) with total and site-specific (lung, breast, colorectal, prostate, gastric, head and neck, and pancreatic) cancer incidence and mortality. Methods : This is a meta-analysis of 19 population-based prospective cohort studies with individual participant data for 897,021 European and American adults. For each cohort we calculated hazard ratios (HRs) for the association of smoking exposure with cancer outcomes using Cox regression adjusted for a common set of the most important potential confounding variables. RAPs (in years) were calculated as the ratio of the logarithms of the HRs for a given smoking exposure variable and age. Meta-analyses were employed to summarize cohort-specific HRs and RAPs. Results : Overall, 140,205 subjects had a first incident cancer, and 53,164 died from cancer, during an average follow-up of 12 years. Current smoking advanced the overall risk of developing and dying from cancer by eight and ten years, respectively, compared with never smokers. The greatest advancements in cancer risk and mortality were seen for lung cancer and the least for breast cancer. Smoking cessation was statistically significantly associated with delays in the risk of cancer development and mortality compared with continued smoking. Conclusions: This investigation shows that smoking, even among older adults, considerably advances, and cessation delays, the risk of developing and dying from cancer. These findings may be helpful in more effectively communicating the harmful effects of smoking and the beneficial effect of smoking cessation.
650 7a Medical and Health Sciences2 hsv
650 7a Health Sciences2 hsv
650 7a Public Health, Global Health, Social Medicine and Epidemiology2 hsv
650 7a Medicin och hälsovetenskap2 hsv
650 7a Hälsovetenskaper2 hsv
650 7a Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi2 hsv
650 7a Medical and Health Sciences2 hsv
650 7a Clinical Medicine2 hsv
650 7a Cancer and Oncology2 hsv
650 7a Medicin och hälsovetenskap2 hsv
650 7a Klinisk medicin2 hsv
650 7a Cancer och onkologi2 hsv
653 0a Smoking
653 0a Cancer
653 0a Incidence
653 0a Mortality
653 0a Cohort
653 0a Meta-analysis
7001 a Schöttker, Ben4 aut
7001 a Mons, Ute4 aut
7001 a Jenab, Mazda4 aut
7001 a Freisling, Heinz4 aut
7001 a Bueno-de-Mesquita, Bas4 aut
7001 a O'Doherty, Mark G.4 aut
7001 a Scott, Angela4 aut
7001 a Kee, Frank4 aut
7001 a Stricker, Bruno H.4 aut
7001 a Hofman, Albert4 aut
7001 a de Keyser, Catherine E.4 aut
7001 a Ruiter, Rikje4 aut
7001 a Söderberg, Stefan4 aut
7001 a Jousilahti, Pekka4 aut
7001 a Kuulasmaa, Kari4 aut
7001 a Freedman, Neal D.4 aut
7001 a Wilsgaard, Tom4 aut
7001 a de Groot, Lisette C. P. G. M.4 aut
7001 a Kampman, Ellen4 aut
7001 a Håkansson, Niclas4 aut
7001 a Orsini, Nicola4 aut
7001 a Wolk, Alicja4 aut
7001 a Nilsson, Lena Maria4 aut
7001 a Tjønneland, Anne4 aut
7001 a Pająk, Andrzej4 aut
7001 a Malyutina, Sofia4 aut
7001 a Kubínová, Růžena4 aut
7001 a Tamosiunas, Abdonas4 aut
7001 a Bobak, Martin4 aut
7001 a Katsoulis, Michail4 aut
7001 a Orfanos, Philippos4 aut
7001 a Boffetta, Paolo4 aut
7001 a Trichopoulou, Antonia4 aut
7001 a Brenner, Hermann4 aut
7101 a Umeå universitetb Medicinska fakulteten4 pbl0 268483
7101 a Umeå universitetb Medicinska fakulteten4 pbl0 268483
7101 a Umeå universitetb Arktiskt centrum vid Umeå universitet (Arcum)4 pbl
7102 a Heart Center4 oth
7721 8i channel recordw 18813935
7730 i Värdpublikationt BMC Medicineg 14x 1741-7015
8564 0u http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120629
8564 0u http://dx.doi.org/10.1186/s12916-016-0607-5
8564 0u http://umu.diva-portal.org/smash/get/diva2:953226/FULLTEXT01
9102 s6 710,710a Umeå universitet.b Medicinsk-odontologiska fakultetenu Umeå universitet.b Medicinska fakulteten
9102 s6 710,710a Medicinska fakulteten vid Umeå universitetu Umeå universitet.b Medicinska fakulteten
841 5 APISa x ab 160906||0000|||||001||||||000000e 1
0247 5 APISa urn:nbn:se:umu:diva-1206292 urn
852 5 APISb APIS
8564 05 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-120629

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