Sökning: onr:"20006150" >
Circulating Folate ...
Circulating Folate and Vitamin B12 and Risk of Prostate Cancer A Collaborative Analysis of Individual Participant Data from Six Cohorts Including 6875 Cases and 8104 Controls
-
Price, Alison J (författare)
-
Travis, Ruth C (författare)
-
Appleby, Paul N (författare)
-
visa fler...
-
Albanes, Demetrius (författare)
-
Barricarte Gurrea, Aurelio (författare)
-
Bjørge, Tone (författare)
-
Bueno-de-Mesquita, H Bas (författare)
-
Chen, Chu (författare)
-
Donovan, Jenny (författare)
-
Gislefoss, Randi (författare)
-
Goodman, Gary (författare)
-
Gunter, Marc (författare)
-
Hamdy, Freddie C (författare)
-
Johansson, Mattias (författare)
-
King, Irena B (författare)
-
Kühn, Tilman (författare)
-
Männistö, Satu (författare)
-
Martin, Richard M (författare)
-
Meyer, Klaus (författare)
-
Neal, David E (författare)
-
Neuhouser, Marian L (författare)
-
Nygård, Ottar (författare)
-
Stattin, Pär (författare)
-
Tell, Grethe S (författare)
-
Trichopoulou, Antonia (författare)
-
Tumino, Rosario (författare)
-
Ueland, Per Magne (författare)
-
Ulvik, Arve (författare)
-
de Vogel, Stefan (författare)
-
Vollset, Stein Emil (författare)
-
Weinstein, Stephanie J (författare)
-
Key, Timothy J (författare)
-
Allen, Naomi E (författare)
-
visa färre...
-
(utgivare)
-
(utgivare)
- 2016
- 2016
- Engelska.
-
Ingår i: European Urology. - 0302-2838. ; 70:6, 941-951
Abstract
Ämnesord
Stäng
- BACKGROUND: Folate and vitamin B12 are essential for maintaining DNA integrity and may influence prostate cancer (PCa) risk, but the association with clinically relevant, advanced stage, and high-grade disease is unclear. OBJECTIVE: To investigate the associations between circulating folate and vitamin B12 concentrations and risk of PCa overall and by disease stage and grade. DESIGN, SETTING, AND PARTICIPANTS: A study was performed with a nested case-control design based on individual participant data from six cohort studies including 6875 cases and 8104 controls; blood collection from 1981 to 2008, and an average follow-up of 8.9 yr (standard deviation 7.3). Odds ratios (ORs) of incident PCa by study-specific fifths of circulating folate and vitamin B12 were calculated using multivariable adjusted conditional logistic regression. OUTCOME MEASUREMENTS AND STATISTICAL ANALYSIS: Incident PCa and subtype by stage and grade. RESULTS AND LIMITATIONS: Higher folate and vitamin B12 concentrations were associated with a small increase in risk of PCa (ORs for the top vs bottom fifths were 1.13 [95% confidence interval (CI), 1.02-1.26], ptrend=0.018, for folate and 1.12 [95% CI, 1.01-1.25], ptrend=0.017, for vitamin B12), with no evidence of heterogeneity between studies. The association with folate varied by tumour grade (pheterogeneity<0.001); higher folate concentration was associated with an elevated risk of high-grade disease (OR for the top vs bottom fifth: 2.30 [95% CI, 1.28-4.12]; ptrend=0.001), with no association for low-grade disease. There was no evidence of heterogeneity in the association of folate with risk by stage or of vitamin B12 with risk by stage or grade of disease (pheterogeneity>0.05). Use of single blood-sample measurements of folate and B12 concentrations is a limitation. CONCLUSIONS: The association between higher folate concentration and risk of high-grade disease, not evident for low-grade disease, suggests a possible role for folate in the progression of clinically relevant PCa and warrants further investigation. PATIENT SUMMARY: Folate, a vitamin obtained from foods and supplements, is important for maintaining cell health. In this study, however, men with higher blood folate levels were at greater risk of high-grade (more aggressive) prostate cancer compared with men with lower folate levels. Further research is needed to investigate the possible role of folate in the progression of this disease.
Ämnesord
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Urology and Nephrology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Urologi och njurmedicin (hsv)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
-
Price, Alison J
-
Travis, Ruth C
-
Appleby, Paul N
-
Albanes, Demetri ...
-
Barricarte Gurre ...
-
Bjørge, Tone
-
visa fler...
-
Bueno-de-Mesquit ...
-
Chen, Chu
-
Donovan, Jenny
-
Gislefoss, Randi
-
Goodman, Gary
-
Gunter, Marc
-
Hamdy, Freddie C
-
Johansson, Matti ...
-
King, Irena B
-
Kühn, Tilman
-
Männistö, Satu
-
Martin, Richard ...
-
Meyer, Klaus
-
Neal, David E
-
Neuhouser, Maria ...
-
Nygård, Ottar
-
Stattin, Pär
-
Tell, Grethe S
-
Trichopoulou, An ...
-
Tumino, Rosario
-
Ueland, Per Magn ...
-
Ulvik, Arve
-
de Vogel, Stefan
-
Vollset, Stein E ...
-
Weinstein, Steph ...
-
Key, Timothy J
-
Allen, Naomi E
-
visa färre...
- Av lärosätet
-
Swepub_uni:_t