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Endostatin, Catheps...
Endostatin, Cathepsin S, and Cathepsin L, and Their Association with Inflammatory Markers and Mortality in Patients Undergoing Hemodialysis
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Carlsson, Axel C (författare)
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Carrero, Juan-Jesús (författare)
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Stenvinkel, Peter (författare)
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visa fler...
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Bottai, Matteo (författare)
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Barany, Peter (författare)
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Larsson, Anders (författare)
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Ärnlöv, Johan (författare)
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visa färre...
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(utgivare)
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(utgivare)
- 2015
- 2015
- Engelska.
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Ingår i: Blood Purification. - 0253-5068. ; 39:4, 259-265
Abstract
Ämnesord
Stäng
- BACKGROUND/AIMS: Although both endostatin and cathepsins S have been associated with higher mortality, data in patients with end-stage renal disease (ESRD) are scarce. METHODS: A longitudinal cohort study of 207 prevalent patients undergoing hemodialysis. RESULTS: Cathepsins S and L were associated with soluble receptors for tumor necrosis factor (sTNFR1 and sTNFR2, rho between 0.28 and 0.43, p < 0.001 for all). Weaker or absent associations between endostatin, cathepsins S and L were seen with other inflammatory biomarkers, that is, CRP, interleukin 6, pentraxin 3, and TNF. In Cox and Laplace regression models adjusted for age, sex, dialysis vintage, and diabetes: standard deviation increments of endostatin was associated with a lower mortality (hazard ratio 0.75, 95% confidence interval (CI) 0.57-0.98), and with 6.8 months longer median survival. CONCLUSIONS: The high levels of endostatin, cathepsins S and L, and their associations with sTNFR1 and sTNFR2 warrant further studies exploring mortality, and the angiogenic and inflammatory pathways in ESRD.
Ämnesord
- Medical and Health Sciences (hsv)
- Health Sciences (hsv)
- Public Health, Global Health, Social Medicine and Epidemiology (hsv)
- Medicin och hälsovetenskap (hsv)
- Hälsovetenskaper (hsv)
- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv)
- Medical and Health Sciences (hsv)
- Clinical Medicine (hsv)
- Hematology (hsv)
- Medicin och hälsovetenskap (hsv)
- Klinisk medicin (hsv)
- Hematologi (hsv)
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