Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemia

doi:10.1038/ncomms10933

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Fältnamn	Indikatorer	Metadata
000		07242naa a22018973a 4500
001		20195160
003		SE-LIBR
005		20170323192050.0
007		cr\|\|\|\|\|\|\|\|\|\|\|\|
008		170323s2016 sw \|\|\|\| o \|\|\|\| \|\|eng c
024	7	a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2828322 uri
024	7	a urn:nbn:se:uu:diva-2828322 urn
024	7	a 10.1038/ncomms109332 doi
040		a S
041	0	a eng
042		9 EPLK
100	1	a Berndt, Sonja I.4 aut
245	1 0	a Meta-analysis of genome-wide association studies discovers multiple loci for chronic lymphocytic leukemiah [Elektronisk resurs]
260		c 2016
500		a Published
500		a Cancerfonden [02 6661]
500		a Stockholms läns landsting [20110209]
506	0	a gratis
520		a Chronic lymphocytic leukemia (CLL) is a common lymphoid malignancy with strong heritability. To further understand the genetic susceptibility for CLL and identify common loci associated with risk, we conducted a meta-analysis of four genome-wide association studies (GWAS) composed of 3,100 cases and 7,667 controls with follow-up replication in 1,958 cases and 5,530 controls. Here we report three new loci at 3p24.1 (rs9880772, EOMES, P = 2.55 x 10(-11)), 6p25.2 (rs73718779, SERPINB6, P = 1.97 x 10(-8)) and 3q28 (rs9815073, LPP, P = 3.62 x 10(-8)), as well as a new independent SNP at the known 2q13 locus (rs9308731, BCL2L11, P = 1.00 x 10(-11)) in the combined analysis. We find suggestive evidence (P<5 x 10(-7)) for two additional new loci at 4q24 (rs10028805, BANK1, P = 7.19 x 10(-8)) and 3p22.2 (rs1274963, CSRNP1, P = 2.12 x 10(-7)). Pathway analyses of new and known CLL loci consistently show a strong role for apoptosis, providing further evidence for the importance of this biological pathway in CLL susceptibility.
650	7	a Medical and Health Sciences2 hsv
650	7	a Medicin och hälsovetenskap2 hsv
700	1	a Camp, Nicola J.4 aut
700	1	a Skibola, Christine F.4 aut
700	1	a Vijai, Joseph4 aut
700	1	a Wang, Zhaoming4 aut
700	1	a Gu, Jian4 aut
700	1	a Nieters, Alexandra4 aut
700	1	a Kelly, Rachel S.4 aut
700	1	a Smedby, Karin E.4 aut
700	1	a Monnereau, Alain4 aut
700	1	a Cozen, Wendy4 aut
700	1	a Cox, Angela4 aut
700	1	a Wang, Sophia S.4 aut
700	1	a Lan, Qing4 aut
700	1	a Teras, Lauren R.4 aut
700	1	a Machado, Moara4 aut
700	1	a Yeager, Meredith4 aut
700	1	a Brooks-Wilson, Angela R.4 aut
700	1	a Hartge, Patricia4 aut
700	1	a Purdue, Mark P.4 aut
700	1	a Birmann, Brenda M.4 aut
700	1	a Vajdic, Claire M.4 aut
700	1	a Cocco, Pierluigi4 aut
700	1	a Zhang, Yawei4 aut
700	1	a Giles, Graham G.4 aut
700	1	a Zeleniuch-Jacquotte, Anne4 aut
700	1	a Lawrence, Charles4 aut
700	1	a Montalvan, Rebecca4 aut
700	1	a Burdett, Laurie4 aut
700	1	a Hutchinson, Amy4 aut
700	1	a Ye, Yuanqing4 aut
700	1	a Call, Timothy G.4 aut
700	1	a Shanafelt, Tait D.4 aut
700	1	a Novak, Anne J.4 aut
700	1	a Kay, Neil E.4 aut
700	1	a Liebow, Mark4 aut
700	1	a Cunningham, Julie M.4 aut
700	1	a Allmer, Cristine4 aut
700	1	a Hjalgrim, Henrik4 aut
700	1	a Adami, Hans-Olov4 aut
700	1	a Melbye, Mads4 aut
700	1	a Glimelius, Bengt4 aut
700	1	a Chang, Ellen T.4 aut
700	1	a Glenn, Martha4 aut
700	1	a Curtin, Karen4 aut
700	1	a Cannon-Albright, Lisa A.4 aut
700	1	a Diver, W. Ryan4 aut
700	1	a Link, Brian K.4 aut
700	1	a Weiner, George J.4 aut
700	1	a Conde, Lucia4 aut
700	1	a Bracci, Paige M.4 aut
700	1	a Riby, Jacques4 aut
700	1	a Arnett, Donna K.4 aut
700	1	a Zhi, Degui4 aut
700	1	a Leach, Justin M.4 aut
700	1	a Holly, Elizabeth A.4 aut
700	1	a Jackson, Rebecca D.4 aut
700	1	a Tinker, Lesley F.4 aut
700	1	a Benavente, Yolanda4 aut
700	1	a Sala, Nuria4 aut
700	1	a Casabonne, Delphine4 aut
700	1	a Becker, Nikolaus4 aut
700	1	a Boffetta, Paolo4 aut
700	1	a Brennan, Paul4 aut
700	1	a Foretova, Lenka4 aut
700	1	a Maynadie, Marc4 aut
700	1	a McKay, James4 aut
700	1	a Staines, Anthony4 aut
700	1	a Chaffee, Kari G.4 aut
700	1	a Achenbach, Sara J.4 aut
700	1	a Vachon, Celine M.4 aut
700	1	a Goldin, Lynn R.4 aut
700	1	a Strom, Sara S.4 aut
700	1	a Leis, Jose F.4 aut
700	1	a Weinberg, J. Brice4 aut
700	1	a Caporaso, Neil E.4 aut
700	1	a Norman, Aaron D.4 aut
700	1	a De Roos, Anneclaire J.4 aut
700	1	a Morton, Lindsay M.4 aut
700	1	a Severson, Richard K.4 aut
700	1	a Riboli, Elio4 aut
700	1	a Vineis, Paolo4 aut
700	1	a Kaaks, Rudolph4 aut
700	1	a Masala, Giovanna4 aut
700	1	a Weiderpass, Elisabete4 aut
700	1	a Chirlaque, Maria-Dolores4 aut
700	1	a Vermeulen, Roel C. H.4 aut
700	1	a Travis, Ruth C.4 aut
700	1	a Southey, Melissa C.4 aut
700	1	a Milne, Roger L.4 aut
700	1	a Albanese, Demetrius4 aut
700	1	a Virtamo, Jarmo4 aut
700	1	a Weinstein, Stephanie4 aut
700	1	a Clavel, Jacqueline4 aut
700	1	a Zheng, Tongzhang4 aut
700	1	a Holford, Theodore R.4 aut
700	1	a Villano, Danylo J.4 aut
700	1	a Maria, Ann4 aut
700	1	a Spinelli, John J.4 aut
700	1	a Gascoyne, Randy D.4 aut
700	1	a Connors, Joseph M.4 aut
700	1	a Bertrand, Kimberly A.4 aut
700	1	a Giovannucci, Edward4 aut
700	1	a Kraft, Peter4 aut
700	1	a Kricker, Anne4 aut
700	1	a Turner, Jenny4 aut
700	1	a Ennas, Maria Grazia4 aut
700	1	a Ferri, Giovanni M.4 aut
700	1	a Miligi, Lucia4 aut
700	1	a Liang, Liming4 aut
700	1	a Ma, Baoshan4 aut
700	1	a Huang, Jinyan4 aut
700	1	a Crouch, Simon4 aut
700	1	a Park, Ju-Hyun4 aut
700	1	a Chatterjee, Nilanjan4 aut
700	1	a North, Kari E.4 aut
700	1	a Snowden, John A.4 aut
700	1	a Wright, Josh4 aut
700	1	a Fraumeni, Joseph F.4 aut
700	1	a Offit, Kenneth4 aut
700	1	a Wu, Xifeng4 aut
700	1	a de Sanjose, Silvia4 aut
700	1	a Cerhan, James R.4 aut
700	1	a Chanock, Stephen J.4 aut
700	1	a Rothman, Nathaniel4 aut
700	1	a Slager, Susan L.4 aut
710	1 2	a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl
772	1 8	i channel recordw 19753896
773	0 8	i Värdpublikationt Nature Communicationsg 7x 2041-1723
856	4 0	u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282832
856	4 0	u http://dx.doi.org/10.1038/ncomms10933
856	4 0	u http://uu.diva-portal.org/smash/get/diva2:917548/FULLTEXT01
841		5 APISa x ab 170323\|\|0000\|\|\|\|\|001\|\|\|\|\|\|000000e 1
024	7	5 APISa urn:nbn:se:uu:diva-2828322 urn
852		5 APISb APIS
856	4 0	5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-282832

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Av författaren/redakt...: Berndt, Sonja I.; Camp, Nicola J.; Skibola, Christi ...; Vijai, Joseph; Wang, Zhaoming; Gu, Jian; visa fler...; Nieters, Alexand ...; Kelly, Rachel S.; Smedby, Karin E.; Monnereau, Alain; Cozen, Wendy; Cox, Angela; Wang, Sophia S.; Lan, Qing; Teras, Lauren R.; Machado, Moara; Yeager, Meredith; Brooks-Wilson, A ...; Hartge, Patricia; Purdue, Mark P.; Birmann, Brenda ...; Vajdic, Claire M ...; Cocco, Pierluigi; Zhang, Yawei; Giles, Graham G.; Zeleniuch-Jacquo ...; Lawrence, Charle ...; Montalvan, Rebec ...; Burdett, Laurie; Hutchinson, Amy; Ye, Yuanqing; Call, Timothy G.; Shanafelt, Tait ...; Novak, Anne J.; Kay, Neil E.; Liebow, Mark; Cunningham, Juli ...; Allmer, Cristine; Hjalgrim, Henrik; Adami, Hans-Olov; Melbye, Mads; Glimelius, Bengt; Chang, Ellen T.; Glenn, Martha; Curtin, Karen; Cannon-Albright, ...; Diver, W. Ryan; Link, Brian K.; Weiner, George J ...; Conde, Lucia; Bracci, Paige M.; Riby, Jacques; Arnett, Donna K.; Zhi, Degui; Leach, Justin M.; Holly, Elizabeth ...; Jackson, Rebecca ...; Tinker, Lesley F ...; Benavente, Yolan ...; Sala, Nuria; Casabonne, Delph ...; Becker, Nikolaus; Boffetta, Paolo; Brennan, Paul; Foretova, Lenka; Maynadie, Marc; McKay, James; Staines, Anthony; Chaffee, Kari G.; Achenbach, Sara ...; Vachon, Celine M ...; Goldin, Lynn R.; Strom, Sara S.; Leis, Jose F.; Weinberg, J. Bri ...; Caporaso, Neil E ...; Norman, Aaron D.; De Roos, Annecla ...; Morton, Lindsay ...; Severson, Richar ...; Riboli, Elio; Vineis, Paolo; Kaaks, Rudolph; Masala, Giovanna; Weiderpass, Elis ...; Chirlaque, Maria ...; Vermeulen, Roel ...; Travis, Ruth C.; Southey, Melissa ...; Milne, Roger L.; Albanese, Demetr ...; Virtamo, Jarmo; Weinstein, Steph ...; Clavel, Jacqueli ...; Zheng, Tongzhang; Holford, Theodor ...; Villano, Danylo ...; Maria, Ann; Spinelli, John J ...; Gascoyne, Randy ...; Connors, Joseph ...; Bertrand, Kimber ...; Giovannucci, Edw ...; Kraft, Peter; Kricker, Anne; Turner, Jenny; Ennas, Maria Gra ...; Ferri, Giovanni ...; Miligi, Lucia; Liang, Liming; Ma, Baoshan; Huang, Jinyan; Crouch, Simon; Park, Ju-Hyun; Chatterjee, Nila ...; North, Kari E.; Snowden, John A.; Wright, Josh; Fraumeni, Joseph ...; Offit, Kenneth; Wu, Xifeng; de Sanjose, Silv ...; Cerhan, James R.; Chanock, Stephen ...; Rothman, Nathani ...; Slager, Susan L.; visa färre...

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