Sökning: onr:"20515385" > Association Between...
Fältnamn | Indikatorer | Metadata |
---|---|---|
000 | 03796naa a22005413a 4500 | |
001 | 20515385 | |
003 | SE-LIBR | |
005 | 20170411151844.0 | |
007 | cr|||||||||||| | |
008 | 170411s2016 sw |||| o |||| ||eng c | |
024 | 7 | a http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-2814782 uri |
024 | 7 | a urn:nbn:se:uu:diva-2814782 urn |
024 | 7 | a 10.1007/s40261-015-0372-92 doi |
040 | a S | |
041 | 0 | a eng |
042 | 9 EPLK | |
100 | 1 | a Hasvold, Pal4 aut |
245 | 1 0 | a Association Between Paradoxical HDL Cholesterol Decrease and Risk of Major Adverse Cardiovascular Events in Patients Initiated on Statin Treatment in a Primary Care Settingh [Elektronisk resurs] |
260 | c 2016 | |
500 | a Published | |
500 | a AstraZeneca | |
506 | 0 | a gratis |
520 | a Background and Objectives Statin-induced changes in high-density lipoprotein cholesterol (HDL-C) and low-density lipoprotein cholesterol (LDL-C) are unrelated. Many patients initiated on statins experience a paradoxical decrease in HDL-C. The aim of this study was to evaluate the association between a decrease in HDL-C and risk of major adverse cardiovascular events (MACE). Methods Data from 15,357 primary care patients initiated on statins during 2004-2009 were linked with data from mandatory national hospital, drug-dispensing, and cause-of-death registers, and were grouped according to HDL-C change: decreased >= 0.1 mmol/L, unchanged +/- 0.1 or >= 0.1 mmol/L increased. To evaluate the association between decrease in HDL-C and risk of MACE, a sample of propensity score-matched patients from the decreased and unchanged groups was created, using the latter group as reference. MACE was defined as myocardial infarction, unstable angina pectoris, ischaemic stroke, or cardiovascular mortality. Cox proportional hazards models were used to estimate relative risks. Results HDL-C decreased in 20 %, was unchanged in 58%, and increased in 22 % of patients initiated on statin treatment (96 % treated with simvastatin). The propensity score-matched sample comprised 5950 patients with mean baseline HDL-C and LDL-C of 1.69 and 4.53 mmol/L, respectively. HDL-C decrease was associated with 56 % higher MACE risk (hazard ratio 1.56; 95 % confidence interval 1.12-2.16; p < 0.01) compared with the unchanged HDL-C group. Conclusions Paradoxical statin-induced reduction in HDL-C was relatively common and was associated with increased risk of MACE. | |
650 | 7 | a Medical and Health Sciences2 hsv |
650 | 7 | a Basic Medicine2 hsv |
650 | 7 | a Pharmacology and Toxicology2 hsv |
650 | 7 | a Medicin och hälsovetenskap2 hsv |
650 | 7 | a Medicinska grundvetenskaper2 hsv |
650 | 7 | a Farmakologi och toxikologi2 hsv |
700 | 1 | a Thuresson, Marcus4 aut |
700 | 1 | a Sundstrom, Johan4 aut |
700 | 1 | a Hammar, Niklas4 aut |
700 | 1 | a Kjeldsen, Sverre E.4 aut |
700 | 1 | a Johansson, Gunnar4 aut |
700 | 1 | a Holme, Ingar4 aut |
700 | 1 | a Bodegard, Johan4 aut |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
710 | 1 2 | a Uppsala universitetb Medicinska och farmaceutiska vetenskapsområdet4 pbl |
772 | 1 8 | i channel recordw 19753896 |
773 | 0 8 | i Värdpublikationt Clinical drug investigationg 36:3, 225-233x 1173-2563 |
856 | 4 0 | u http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281478 |
856 | 4 0 | u http://dx.doi.org/10.1007/s40261-015-0372-9 |
856 | 4 0 | u http://uu.diva-portal.org/smash/get/diva2:915371/FULLTEXT01 |
841 | 5 APISa x ab 170411||0000|||||001||||||000000e 1 | |
024 | 7 | 5 APISa urn:nbn:se:uu:diva-2814782 urn |
852 | 5 APISb APIS | |
856 | 4 0 | 5 APISu http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-281478 |
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