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eGFR and the risk o...
eGFR and the risk of community-acquired infections
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- Xu, Hong (författare)
- Karolinska Institutet
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- Gasparini, Alessandro (författare)
- Karolinska Institutet
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- Ishigami, Junichi (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
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- Mzayen, Khaled (författare)
- Karolinska Inst, Dept Publ Hlth, Stockholm, Sweden.
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- Su, Guobin (författare)
- Karolinska Institutet
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- Barany, Peter (författare)
- Karolinska Institutet
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- Ärnlöv, Johan, 1970- (författare)
- Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Uppsala universitet,Institutionen för medicinska vetenskaper,Dalarna Univ, Sch Hlth & Social Studies, Falun, Sweden
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- Lindholm, Bengt (författare)
- Karolinska Institutet
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- Elinder, Carl Gustaf (författare)
- Karolinska Institutet
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- Carrero, Juan Jesús (författare)
- Karolinska Institutet
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- Matsushita, Kunihiro (författare)
- Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA.
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Karolinska Institutet Johns Hopkins Bloomberg Sch Publ Hlth, Dept Epidemiol, Baltimore, MD USA (creator_code:org_t)
- 2017
- 2017
- Engelska.
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Ingår i: American Society of Nephrology. Clinical Journal. - 1555-9041 .- 1555-905X. ; 12:9, s. 1399-1408
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.2...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND AND OBJECTIVES: Community-acquired infections are common, contributing to adverse outcomes and increased health care costs. We hypothesized that, with lower eGFR, the incidence of community-acquired infections increases, whereas the pattern of site-specific infections varies.DESIGN, SETTING, PARTICIPANTS, & MEASUREMENTS: Among 1,139,470 health care users (mean age =52±18 years old, 53% women) from the Stockholm CREAtinine Measurements Project, we quantified the associations of eGFR with the risk of infections, overall and major types, over 12 months.RESULTS: A total of 106,807 counts of infections were recorded throughout 1,128,313 person-years. The incidence rate of all infections increased with lower eGFR from 74/1000 person-years for individuals with eGFR=90-104 ml/min per 1.73 m(2) to 419/1000 person-years for individuals with eGFR<30 ml/min per 1.73 m(2). Compared with eGFR of 90-104 ml/min per 1.73 m(2), the adjusted incidence rate ratios of community-acquired infections were 1.08 (95% confidence interval, 1.01 to 1.14) for eGFR of 30-59 ml/min per 1.73 m(2) and 1.53 (95% confidence interval, 1.39 to 1.69) for eGFR<30 ml/min per 1.73 m(2). The relative proportions of lower respiratory tract infection, urinary tract infection, and sepsis became increasingly higher along with lower eGFR strata (e.g., low respiratory tract infection accounting for 25% versus 15% of community-acquired infections in eGFR<30 versus 90-104 ml/min per 1.73 m(2), respectively). Differences in incidence associated with eGFR were in general consistent for most infection types, except for nervous system and upper respiratory tract infections, for which no association was observed.CONCLUSIONS: This region-representative health care study finds an excess community-acquired infections incidence in individuals with mild to severe CKD. Lower respiratory tract infection, urinary tract infection, and sepsis are major infections in CKD.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Urologi och njurmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Urology and Nephrology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Infektionsmedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Infectious Medicine (hsv//eng)
Nyckelord
- Adult
- Aged
- Communicable Diseases
- Community-Acquired Infections
- Epidemiology and outcomes
- Female
- Health Care Costs
- Humans
- Incidence
- Middle Aged
- Nervous System
- Renal Insufficiency
- Chronic
- Respiratory Tract Infections
- Urinary Tract Infections
- chronic kidney disease
- community
- creatinine
- glomerular filtration rate
- lower respiratory tract infection
- renal function
- risk factors
- sepsis
- urinary tract infections
- Hälsa och välfärd
- Health and Welfare
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Xu, Hong
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Gasparini, Aless ...
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Ishigami, Junich ...
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Mzayen, Khaled
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Su, Guobin
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Barany, Peter
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Ärnlöv, Johan, 1 ...
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Lindholm, Bengt
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Elinder, Carl Gu ...
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Carrero, Juan Je ...
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Matsushita, Kuni ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Urologi och njur ...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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- Av lärosätet
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Högskolan Dalarna
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Uppsala universitet
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Karolinska Institutet