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Albuminuria as a pr...
Albuminuria as a predictor of cardiovascular outcomes in patients with acute myocardial infarction
- Artikel/kapitelEngelska2019
Förlag, utgivningsår, omfång ...
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2019
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electronicrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:du-29863
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https://urn.kb.se/resolve?urn=urn:nbn:se:du-29863URI
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https://doi.org/10.1161/JAHA.118.010546DOI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:141771874URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
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Background. In patients with myocardial infarction ( MI ), reduced kidney function is recognized as an important predictor of poor prognosis, but the impact of albuminuria, a representative measure of kidney damage, has not been extensively evaluated.Methods and Results. In the SCREAM (Stockholm Creatinine Measurements) project (2006-2012), we identified 2469 patients with incident MI with dipstick proteinuria measured within a year before MI (427 patients also had urine albumin to creatinine ratio [ ACR ] measured concurrently) and obtained estimates for ACR with multiple imputation in participants with data solely on dipstick proteinuria. We quantified the association of ACR with the post- MI composite and individual outcomes of all-cause mortality, cardiovascular mortality, recurrent MI , ischemic stroke, or heart failure using Cox models and then evaluated the improvement in C statistic. During a median follow-up of 1.0 year after MI , 1607 participants (65.1%) developed the post- MI composite outcome. Higher ACR levels were independently associated with all outcomes except for ischemic stroke. Per 8-fold higher ACR (eg, 40 versus 5 mg/g), the hazard ratio of composite outcome was 1.21 (95% CI , 1.08-1.35). The addition of the ACR improved the C statistic of the post- MI composite by 0.040 (95% CI, 0.030-0.051). Largely similar results were obtained regardless of diabetic status and when ACR or dipstick was separately analyzed without imputation.Conclusions. In patients with MI , albuminuria was a potent predictor of subsequent outcomes, suggesting the importance of paying attention to the information on albuminuria, in addition to kidney function, in this high-risk population.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Ballew, Shoshana H
(författare)
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Sang, Yingying
(författare)
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Grams, Morgan EKarolinska Institutet
(författare)
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Coresh, Josef
(författare)
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Evans, Marie
(författare)
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Barany, PeterKarolinska Institutet
(författare)
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Ärnlöv, Johan,1970-Karolinska Institutet,Högskolan Dalarna,Medicinsk vetenskap,Karolinska institutet(Swepub:du)jan
(författare)
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Carrero, Juan-JesusKarolinska Institutet
(författare)
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Matsushita, Kunihiro
(författare)
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Karolinska InstitutetMedicinsk vetenskap
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Journal of the American Heart Association8:82047-9980
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Till lärosätets databas
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Mok, Yejin
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Ballew, Shoshana ...
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Sang, Yingying
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Grams, Morgan E
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Coresh, Josef
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Evans, Marie
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visa fler...
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Barany, Peter
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Ärnlöv, Johan, 1 ...
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Carrero, Juan-Je ...
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Matsushita, Kuni ...
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visa färre...
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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Journal of the A ...
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Högskolan Dalarna
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Karolinska Institutet