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Proteomic Analysis ...
Proteomic Analysis of Longitudinal Changes in Blood Pressure
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- Yi-Ting, Lin (författare)
- Uppsala University,Uppsala universitet,Kardiologi,Kaohsiung Med Univ, Kaohsiung Med Univ Hosp, Dept Family Med, Kaohsiung 807, Taiwan,Kaohsiung Medical University Chung-Ho Memorial Hospital
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- Fall, Tove, 1979- (författare)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi
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- Hammar, Ulf (författare)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi
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- Gustafsson, Stefan (författare)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi
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- Ingelsson, Erik, 1975- (författare)
- Uppsala University,Uppsala universitet,Molekylär epidemiologi,Stanford Univ, Dept Med, Div Cardiovasc Med, Sch Med, Stanford, CA 94305 USA; Stanford Univ, Stanford Cardiovasc Inst, Stanford, CA 94305 USA; Stanford Univ, Stanford Diabet Res Ctr, Stanford, CA 94305 USA,Stanford University
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- Ärnlöv, Johan, 1970- (författare)
- Dalarna University College,Högskolan Dalarna,Medicinsk vetenskap,Karolinska Institutet,Karolinska Inst, Dept Neurobiol Care Sci & Soc, Div Family Med & Primary Care, S-14152 Huddinge, Sweden; Dalarna Univ, Sch Hlth & Social Studies, S-79131 Falun, Sweden
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- Lind, Lars (författare)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi
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- Engström, Gunnar (författare)
- Lund University,Lunds universitet,Kardiovaskulär forskning - epidemiologi,Forskargrupper vid Lunds universitet,Cardiovascular Research - Epidemiology,Lund University Research Groups
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- Sundström, Johan, Professor, 1971- (författare)
- Uppsala University,Uppsala universitet,Klinisk epidemiologi,Univ New South Wales, George Inst Global Hlth, Sydney, NSW 2042, Australia,University of New South Wales
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(creator_code:org_t)
- 2019-10-02
- 2019
- Engelska.
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Ingår i: Journal of Clinical Medicine. - : MDPI AG. - 2077-0383. ; 8:10
- Relaterad länk:
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https://doi.org/10.3...
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https://du.diva-port... (primary) (Raw object)
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https://www.mdpi.com...
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https://uu.diva-port... (primary) (Raw object)
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http://dx.doi.org/10... (free)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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http://kipublication...
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https://lup.lub.lu.s...
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Abstract
Ämnesord
Stäng
- Hypertension is the leading risk factor for premature death worldwide. The identification of modifiable causes of hypertension remains an imperative task. We aimed to investigate associations between 79 proteins implicated in cardiovascular disease and longitudinal blood pressure (BP) changes in three Swedish prospective cohorts. In a discovery phase, we investigated associations between baseline circulating protein levels assessed with a proximity extension assay and BP stage progression at follow-up 5 years later among persons without BP-lowering drugs at baseline in two independent community-based cohorts from the Prospective Investigation of the Vasculature in Uppsala Seniors study (PIVUS) and the Uppsala Longitudinal Study of Adult Men (ULSAM). We used an independent cohort, the Malmö Diet and Cancer Study (MDC), for replication. The primary outcome of BP stage progression was defined as per the 2017 AHA/ACC (American Heart Association/ American College of Cardiology) Guideline BP categories. We also investigated associations of protein levels with changes in BP on a continuous scale, and meta-analyzed all three cohorts. Levels of renin were associated with BP stage progression with a 5% false discovery rate (FDR) in the ULSAM (n = 238) and PIVUS (n = 566) cohorts, but we could not replicate this association in the MDC cohort (n = 2659). The association in the discovery cohorts was modest, with an odds ratio for BP stage progression over 5 years of 1.33 (95% confidence interval 1.14 to 1.56) per standard deviation of baseline renin. In conclusion, we could not find any novel robust associations with longitudinal BP increase in a proximity extension assay-based proteomics investigation in three cohorts.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Kardiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Cardiac and Cardiovascular Systems (hsv//eng)
Nyckelord
- blood pressure
- hypertension
- prospective cohort
- proteomics
- Health and Welfare
- Hälsa och välfärd
- Blood pressure
- Hypertension
- Prospective cohort
- Proteomics
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Yi-Ting, Lin
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Fall, Tove, 1979 ...
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Hammar, Ulf
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Gustafsson, Stef ...
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Ingelsson, Erik, ...
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Ärnlöv, Johan, 1 ...
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Lind, Lars
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Engström, Gunnar
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Sundström, Johan ...
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- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Kardiologi
- Artiklar i publikationen
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Journal of Clini ...
- Av lärosätet
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Högskolan Dalarna
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Uppsala universitet
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Karolinska Institutet
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Lunds universitet