onr:"swepub:oai:DiVA.org:gih-2587"
Sökning: onr:"swepub:oai:DiVA.org:gih-2587" > Cardiorespiratory f...
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
- Larsen, Filip JKarolinska Institutet,Gymnastik- och idrottshögskolan,Björn Ekbloms forskningsgrupp (författare)
Cardiorespiratory fitness predicts insulin action and secretion in healthy individuals.
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
- Elsevier BV,2012
- printrdacarrier
Nummerbeteckningar
- LIBRIS-ID:oai:DiVA.org:gih-2587
- https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-2587URI
- https://doi.org/10.1016/j.metabol.2011.05.010DOI
- http://kipublications.ki.se/Default.aspx?queryparsed=id:123775513URI
Kompletterande språkuppgifter
- Språk:engelska
- Sammanfattning på:engelska
Ingår i deldatabas
- SwePubSwePub
Klassifikation
Anmärkningar
- Long-term cardiorespiratory fitness (CRF) and the development of type 2 diabetes mellitus are inversely correlated. Here, we examined the relationships between peak oxygen uptake (VO(2)peak), on the one hand, and glucose infusion rate at rest (GIR(rest)) and during exercise (GIR(exercise)), as well as insulin secretion (both the early and late phases of response [area under the curve {AUC}(insulin)]), on the other. Eight male and 4 female healthy, lean, nonsmoking volunteers were recruited. The VO(2)peak was measured during graded exercise on a cycle ergometer until exhaustion was reached. The GIR(rest) and GIR(exercise) were determined using a euglycemic-hyperinsulinemic clamp, and insulin secretion at rest was evaluated with an intravenous glucose tolerance test. The VO(2)peak correlated positively to GIR(rest) (r = 0.81, P = .001) and GIR(exercise) (r = 0.87, P < .001) and negatively to AUC(insulin) (r = -0.64, P = .03). The respiratory exchange ratio (RER) during insulin infusion was positively correlated to GIR(rest) (r = 0.83, P < .001) and GIR(exercise) (r = 0.86, P < .01) and negatively correlated to both the early insulin response (r = -0.86, P < .0001) and AUC(insulin) (r = -0.87, P = .001). The VO(2)peak accounted for 45% of the variability in RER (R(2) = 0.45, P = .035). In this healthy population, CRF and RER were highly correlated to insulin sensitivity and secretion, as well as to the ability to alter the substrate being oxidized during exercise. These findings highlight the importance of good CRF to maintaining normal insulin action.
Ämnesord och genrebeteckningar
- Medicin/Teknik
- Medicine/Technology
Biuppslag (personer, institutioner, konferenser, titlar ...)
- Anderson, MartinKarolinska Institutet (författare)
- Ekblom, BjörnGymnastik- och idrottshögskolan,Björn Ekbloms forskningsgrupp(Swepub:gih)bjorne (författare)
- Nyström, ThomasKarolinska Institutet (författare)
- Gymnastik- och idrottshögskolanBjörn Ekbloms forskningsgrupp (creator_code:org_t)
Sammanhörande titlar
- Ingår i:Metabolism: Elsevier BV61:1, s. 12-60026-04951532-8600
Internetlänk
- 1 av 1
- Föregående post
- Nästa post
- Till träfflistan
Hitta mer i SwePub
- Av författaren/redakt...
- Larsen, Filip J
- Anderson, Martin
- Ekblom, Björn
- Nyström, Thomas
- Artiklar i publikationen
- Metabolism
- Av lärosätet
- Gymnastik- och idrottshögskolan
- Karolinska Institutet
Sök utanför SwePub
- Sök vidare i:
- Google Book Search
- Google Scholar
Kungliga biblioteket hanterar dina personuppgifter i enlighet med EU:s dataskyddsförordning (2018), GDPR. Läs mer om hur det funkar här.
Så här hanterar KB dina uppgifter vid användning av denna tjänst.
- Copyright © LIBRIS - Nationella bibliotekssystem
- LIBRIS.kb.se
