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Cerebral Small Vess...
Cerebral Small Vessel Disease Associated With Atrial Fibrillation Among Older Adults : A Population-Based Study.
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- Ding, Mozhu (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Stockholm University, Sweden
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- Wang, Rui (författare)
- Stockholms universitet,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,Karolinska Institutet, Stockholm University, Sweden,Fysisk aktivitet och hjärnhälsa,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),The Swedish School of Sport and Health Sciences, GIH, Sweden; University of Wisconsin School of Medicine and Public Health, USA
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- Kalpouzos, Grégoria (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Stockholm, Sweden.
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- Laukka, Erika J (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Stockholm, Sweden; Stockholm Gerontology Research Center, Sweden
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- Li, Yuanjing (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Stockholm University, Sweden
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- Johnell, Kristina (författare)
- Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
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- Fratiglioni, Laura (författare)
- Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Stockholm University, Sweden; Stockholm Gerontology Research Center, Sweden
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- Qiu, Chengxuan (författare)
- Karolinska Institutet,Stockholms universitet,Centrum för forskning om äldre och åldrande (ARC), (tills m KI),Karolinska Institutet, Stockholm University, Sweden
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(creator_code:org_t)
- American Heart Association, 2021
- 2021
- Engelska.
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Ingår i: Stroke. - : American Heart Association. - 0039-2499 .- 1524-4628. ; 52:8, s. 2685-2689
- Relaterad länk:
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https://gih.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND AND PURPOSE: Cerebral small vessel disease, as a potential mechanism underlying the association between atrial fibrillation (AF) and dementia, remains poorly investigated. In this cohort study, we sought to examine the association between AF and cerebral small vessel disease markers among older adults.METHODS: Data on 336 participants (age ≥60 years, mean 70.2 years; 60.2% women) free of dementia, disability, and cerebral infarcts were derived from the population-based Swedish National Study on Aging and Care in Kungsholmen. Structural brain magnetic resonance imaging examinations were performed at baseline (2001-2004) and follow-ups (2004-2007 and 2007-2010). Magnetic resonance imaging markers of cerebral small vessel disease included perivascular spaces, lacunes, and volumes of white matter hyperintensities, lateral ventricles, and total brain tissue. AF was assessed at baseline and follow-ups through clinical examinations, electrocardiogram, and medical records. Data were analyzed using linear mixed-effects models.RESULTS: At baseline, 18 persons (5.4%) were identified to have prevalent AF and 17 (5.6%) developed incident AF over the 6-year follow-up. After multivariable adjustment, AF was significantly associated with a faster annual increase in white matter hyperintensities volume (β coefficient=0.45 [95% CI, 0.04-0.86]) and lateral ventricular volume (0.58 [0.13-1.02]). There was no significant association of AF with annual changes in perivascular spaces number (β coefficient=0.53 [95% CI, -0.27 to 1.34]) or lacune number (-0.01 [-0.07 to 0.05]).CONCLUSIONS: Independent of cerebral infarcts, AF is associated with accelerated progression of white matter lesions and ventricular enlargement among older adults.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Neurologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Neurology (hsv//eng)
Nyckelord
- atrial fibrillation
- cerebral infarction
- cerebral small vessel diseases
- dementia
- magnetic resonance imaging
- Medicin/Teknik
- Medicine/Technology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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