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Acute cellular and ...
Acute cellular and molecular responses and chronic adaptations to low-load blood flow restriction and high-load resistance exercise in trained individuals.
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- Davids, Charlie J (författare)
- University of Queensland, Brisbane, Australia; Queensland Academy of Sport, Nathan, Australia
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- Næss, Tore C (författare)
- Department of Physical Performance, Norwegian School of Sport Science, Oslo, Norway.
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- Moen, Maria (författare)
- Department of Physical Performance, Norwegian School of Sport Science, Oslo, Norway.
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- Cumming, Kristoffer Toldnes (författare)
- Department of Physical Performance, Norwegian School of Sport Science, Oslo, Norway.
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- Horwath, Oscar, 1991- (författare)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Psilander, Niklas (författare)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Ekblom, Björn, 1938- (författare)
- Gymnastik- och idrottshögskolan,Institutionen för fysiologi, nutrition och biomekanik
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- Coombes, Jeff S (författare)
- University of Queensland, Brisbane, Australia.
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- Peake, Jonathan M (författare)
- Queensland Academy of Sport, Nathan, Australia; Queensland University of Technology, School of Biomedical Science, Brisbane, Australia
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- Raastad, Truls (författare)
- Department of Physical Performance, Norwegian School of Sport Science, Oslo, Norway.
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- Roberts, Llion Arwyn (författare)
- University of Queensland, Brisbane, Australia; Queensland Academy of Sport, Nathan, Australia; Griffith University, Gold Coast, Australia
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University of Queensland, Brisbane, Australia; Queensland Academy of Sport, Nathan, Australia Department of Physical Performance, Norwegian School of Sport Science, Oslo, Norway (creator_code:org_t)
- American Physiological Society, 2021
- 2021
- Engelska.
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Ingår i: Journal of applied physiology. - : American Physiological Society. - 8750-7587 .- 1522-1601. ; 131:6, s. 1731-1749
- Relaterad länk:
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https://research-rep...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Blood flow restriction (BFR) with low-load resistance exercise (RE) is often used as a surrogate to traditional high-load RE to stimulate muscular adaptations, such as hypertrophy and strength. However, it is not clear whether such adaptations are achieved through similar cellular and molecular processes. We compared changes in muscle function, morphology and signaling pathways between these differing training protocols. Twenty-one males and females (mean ± SD: 24.3 ± 3.1 years) experienced with resistance training (4.9 ± 2.6 years) performed nine weeks of resistance training (three times per week) with either high-loads (75-80% 1RM; HL-RT), or low-loads with BFR (30-40% 1RM; LL-BFR). Before and after the training intervention, resting muscle biopsies were collected, and quadricep cross-sectional area (CSA), muscular strength and power were measured. Approximately 5 days following the intervention, the same individuals performed an additional 'acute' exercise session under the same conditions, and serial muscle biopsies were collected to assess hypertrophic- and ribosomal-based signaling stimuli. Quadricep CSA increased with both LL-BFR (7.4±4.3%) and HL-RT (4.6±2.9%), with no significant differences between training groups (p=0.37). Muscular strength also increased in both training groups, but with superior gains in squat 1RM occurring with HL-RT (p<0.01). Acute phosphorylation of several key proteins involved in hypertrophy signaling pathways, and expression of ribosomal RNA transcription factors occurred to a similar degree with LL-BFR and HL-RT (all p>0.05 for between-group comparisons). Together, these findings validate low-load resistance training with continuous BFR as an effective alternative to traditional high-load resistance training for increasing muscle hypertrophy in trained individuals.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Idrottsvetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Sport and Fitness Sciences (hsv//eng)
Nyckelord
- Hypertrophy
- Hypoxia
- Ischemia
- Kaatsu
- Occlusion
- Medicin/Teknik
- Medicine/Technology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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Davids, Charlie ...
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Næss, Tore C
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Moen, Maria
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Cumming, Kristof ...
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Horwath, Oscar, ...
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Psilander, Nikla ...
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visa fler...
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Ekblom, Björn, 1 ...
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Coombes, Jeff S
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Peake, Jonathan ...
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Raastad, Truls
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Roberts, Llion A ...
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