Sökning: onr:"swepub:oai:DiVA.org:gih-6980" > Age-related differe...
Fältnamn | Indikatorer | Metadata |
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000 | 05347naa a2200685 4500 | |
001 | oai:DiVA.org:gih-6980 | |
003 | SwePub | |
008 | 220222s2022 | |||||||||||000 ||eng| | |
009 | oai:prod.swepub.kib.ki.se:236908893 | |
024 | 7 | a https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-69802 URI |
024 | 7 | a https://doi.org/10.1016/j.nbas.2022.1000302 DOI |
024 | 7 | a http://kipublications.ki.se/Default.aspx?queryparsed=id:2369088932 URI |
040 | a (SwePub)gihd (SwePub)ki | |
041 | a engb eng | |
042 | 9 SwePub | |
072 | 7 | a ref2 swepub-contenttype |
072 | 7 | a art2 swepub-publicationtype |
100 | 1 | a Motovylyak, Aliceu University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
245 | 1 0 | a Age-related differences in white matter microstructure measured by advanced diffusion MRI in healthy older adults at risk for Alzheimer’s disease |
264 | 1 | b Elsevier,c 2022 |
338 | a electronic2 rdacarrier | |
520 | a Neurite orientation dispersion and density imaging (NODDI) is an advanced diffusion imaging technique, which can detect more distinct microstructural features compared to conventional Diffusion Tensor Imaging (DTI). NODDI allows the signal to be divided into multiple water compartments and derive measures for orientation dispersion index (ODI), neurite density index (NDI) and volume fraction of isotropic diffusion compartment (FISO). This study aimed to investigate which diffusion metric—fractional anisotropy (FA), mean diffusivity (MD), NDI, ODI, or FISO—is most influenced by aging and reflects cognitive function in a population of healthy older adults at risk for Alzheimer’s disease (AD). Age was significantly associated with all but one diffusion parameters and regions of interest. NDI and MD in the cingulate region adjacent to the cingulate cortex showed a significant association with a composite measure of Executive Function and was proven to partially mediate the relationship between aging and Executive Function decline. These results suggest that both DTI and NODDI parameters are sensitive to age-related differences in white matter regions vulnerable to aging, particularly among older adults at risk for AD. | |
650 | 7 | a MEDICIN OCH HÄLSOVETENSKAPx Medicinska och farmaceutiska grundvetenskaperx Neurovetenskaper0 (SwePub)301052 hsv//swe |
650 | 7 | a MEDICAL AND HEALTH SCIENCESx Basic Medicinex Neurosciences0 (SwePub)301052 hsv//eng |
653 | a Aging | |
653 | a Alzheimer’s disease (AD) | |
653 | a Diffusion tensor imaging (DTI) | |
653 | a Magnetic resonance imaging (MRI) | |
653 | a Neurite orientation dispersion and density imaging (NODDI) | |
653 | a White matter | |
653 | a E-PABS | |
653 | a EPABS | |
653 | a hjärnhälsa | |
653 | a brain health | |
653 | a Medicin/Teknik | |
653 | a Medicine/Technology | |
700 | 1 | a Vogt, Nicholas M.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
700 | 1 | a Adluru, Nageshu University of Wisconsin, Madison, USA4 aut |
700 | 1 | a Ma, Yueu University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
700 | 1 | a Wang, Ruiu Karolinska Institutet,Gymnastik- och idrottshögskolan,Institutionen för fysisk aktivitet och hälsa,University of Wisconsin School of Medicine and Public Health, Madison, USA,Fysisk aktivitet och hjärnhälsa4 aut0 (Swepub:gih)rui.wang |
700 | 1 | a Oh, Jennifer M.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
700 | 1 | a Kecskemeti, Steven R.u University of Wisconsin, Madison, USA4 aut |
700 | 1 | a Alexander, Andrew L.u University of Wisconsin, Madison, USA4 aut |
700 | 1 | a Dean, Douglas C.u University of Wisconsin, Madison, USA4 aut |
700 | 1 | a Gallagher, Catherine L.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
700 | 1 | a Sager, Mark A.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
700 | 1 | a Hermann, Bruce P.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
700 | 1 | a Rowley, Howard A.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
700 | 1 | a Johnson, Sterling C.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
700 | 1 | a Asthana, Sanjayu University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
700 | 1 | a Bendlin, Barbara B.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
700 | 1 | a Okonkwo, Ozioma C.u University of Wisconsin School of Medicine and Public Health, Madison, USA4 aut |
710 | 2 | a University of Wisconsin School of Medicine and Public Health, Madison, USAb University of Wisconsin, Madison, USA4 org |
773 | 0 | t Aging Braind : Elsevierg 2q 2x 2589-9589 |
856 | 4 | u https://doi.org/10.1016/j.nbas.2022.100030y Fulltext |
856 | 4 | u https://gih.diva-portal.org/smash/get/diva2:1639857/FULLTEXT01.pdfx primaryx Raw objecty fulltext:print |
856 | 4 | u https://doi.org/10.1016/j.nbas.2022.100030 |
856 | 4 8 | u https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-6980 |
856 | 4 8 | u https://doi.org/10.1016/j.nbas.2022.100030 |
856 | 4 8 | u http://kipublications.ki.se/Default.aspx?queryparsed=id:236908893 |
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