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Sökning: onr:"swepub:oai:DiVA.org:gih-955" > Branched-chain amin...

  • Karlsson, Håkan K RKarolinska Institutet (författare)

Branched-chain amino acids increase p70S6k phosphorylation in human skeletal muscle after resistance exercise.

  • Artikel/kapitelEngelska2004

Förlag, utgivningsår, omfång ...

  • American Physiological Society,2004
  • printrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:gih-955
  • https://urn.kb.se/resolve?urn=urn:nbn:se:gih:diva-955URI
  • https://doi.org/10.1152/ajpendo.00430.2003DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:1954209URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

Ingår i deldatabas

Klassifikation

  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • The aim of the study was to investigate the effect of resistance exercise alone or in combination with oral intake of branched-chain amino acids (BCAA) on phosphorylation of the 70-kDa S6 protein kinase (p70(S6k)) and mitogen-activated protein kinase (MAPK), extracellular signal-regulated kinase (ERK1/2), and p38 MAPK in skeletal muscle. Seven male subjects performed one session of quadriceps muscle resistance training (4 x 10 repetitions at 80% of one repetition maximum) on two occasions. In a randomized order, double-blind, crossover test, subjects ingested a solution of BCAA or placebo during and after exercise. Ingestion of BCAA increased plasma concentrations of isoleucine, leucine, and valine during exercise and throughout recovery after exercise (2 h postexercise), whereas no change was noted after the placebo trial. Resistance exercise led to a robust increase in p70(S6k) phosphorylation at Ser(424) and/or Thr(421), which persisted 1 and 2 h after exercise. BCAA ingestion further enhanced p70(S6k) phosphorylation 3.5-fold during recovery. p70(S6k) phosphorylation at Thr(389) was unaltered directly after resistance exercise. However, during recovery, Thr(389) phosphorylation was profoundly increased, but only during the BCAA trial. Furthermore, phosphorylation of the ribosomal protein S6 was also increased in the recovery period only during the BCAA trial. Exercise led to a marked increase in ERK1/2 and p38 MAPK phosphorylation, which was completely suppressed upon recovery and unaltered by BCAA. In conclusion, BCAA, ingested during and after resistance exercise, mediate signal transduction through p70(S6k) in skeletal muscle.

Ämnesord och genrebeteckningar

  • MEDICINE
  • MEDICIN

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Nilsson, Per-Anders (författare)
  • Nilsson, JohnnyGymnastik- och idrottshögskolan,Laboratoriet för biomekanik och motorisk kontroll (BMC)(Swepub:gih)johnnyn (författare)
  • Chibalin, Alexander VKarolinska Institutet (författare)
  • Zierath, Juleen RKarolinska Institutet (författare)
  • Blomstrand, EvaGymnastik- och idrottshögskolan,Eva Blomstrands forskningsgrupp(Swepub:gih)evab (författare)
  • Karolinska InstitutetLaboratoriet för biomekanik och motorisk kontroll (BMC) (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:American Journal of Physiology. Endocrinology and Metabolism: American Physiological Society287:1, s. E1-70193-18491522-1555

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