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Inhibition of dengu...
Inhibition of dengue viral infection by diasarone-I is associated with 2'O methyltransferase of NS5
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- Yao, Xingang (författare)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
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- Ling, Yun (författare)
- Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang, PR China
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- Guo, Songxin (författare)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
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- He, Shijun (författare)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
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- Wang, Jinan (författare)
- Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai, PR China
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- Zhang, Qing (författare)
- Department of Pharmaceutical and Life Sciences, Jiujiang University, Jiujiang, PR China
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- Wu, Wenyu (författare)
- Zhongshan Ophthalmic Center, Sun Yat-sen University, Guangzhou, PR China
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- Zou, Min (författare)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
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- Zhang, Tingting (författare)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
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- Nandakumar, Kutty Selva, 1965- (författare)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
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- Chen, Xiaoguang (författare)
- School of Public Health, Southern Medical University, Southern Medical University, Guangzhou, PR China
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- Liu, Shuwen (författare)
- School of Pharmaceutical Sciences, Southern Medical University, Guangzhou, PR China
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(creator_code:org_t)
- Amsterdam : Elsevier, 2018
- 2018
- Engelska.
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Ingår i: European Journal of Pharmacology. - Amsterdam : Elsevier. - 0014-2999 .- 1879-0712. ; 821, s. 11-20
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Dengue virus (DENV) is the most prevalent mosquito borne viral pathogen worldwide. However, antiviral drugs against this infection are not available. To identify novel anti-DENV compound from traditional Chinese medicine, we discovered the ethanol extract of Acorus tatarinowii Schott containing potent anti-DENV activity and diasarone-I was isolated from this extract. Diasarone-I has antiviral effect with half maximal effective concentration (EC50) of 4.5μM and half maximal cytotoxicity concentration (CC50) of >80μM. Time of drug addition assay suggested that this compound inhibited at RNA replication step in the DENV life cycle. Further, in silico analysis indicated that diasarone-I might act as an inhibitor of 2'O Methyltransferase of NS5. Diasarone-I has also decreased the DENV2-induced STAT1 phosphorylation and ISGs. In summary, we suggest that diasarone-I may be a 2'O Methyltransferase inhibitor and might serve as a potential candidate for the treatment of DENV2 infections. © 2017 Elsevier B.V.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- 2'O methyltransferase
- Acorus tatarinowii Schott
- DENV2
- Diasarone-I
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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- Av författaren/redakt...
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Yao, Xingang
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Ling, Yun
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Guo, Songxin
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He, Shijun
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Wang, Jinan
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Zhang, Qing
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visa fler...
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Wu, Wenyu
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Zou, Min
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Zhang, Tingting
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Nandakumar, Kutt ...
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Chen, Xiaoguang
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Liu, Shuwen
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visa färre...
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