Sökning: onr:"swepub:oai:DiVA.org:hh-48871" >
Genetic control of ...
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Forster, M.Karolinska Institutet, Stockholm, Sweden
(författare)
Genetic control of antibody production during collagen-induced arthritis development in heterogeneous stock mice
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2012-10-27
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Wiley,2012
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:hh-48871
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https://urn.kb.se/resolve?urn=urn:nbn:se:hh:diva-48871URI
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https://doi.org/10.1002/art.34658DOI
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https://lup.lub.lu.se/record/3283464URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:125495607URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124689059URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:124324662URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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OBJECTIVE: To identify genetic factors driving pathogenic autoantibody formation in collagen-induced arthritis (CIA), a mouse model of rheumatoid arthritis (RA), in order to better understand the etiology of RA and identify possible new avenues for therapeutic intervention. METHODS: We performed a genome-wide analysis of quantitative trait loci controlling autoantibody to type II collagen (anti-CII), anti-citrullinated protein antibody (ACPA), and rheumatoid factor (RF). To identify loci controlling autoantibody production, we induced CIA in a heterogeneous stock-derived mouse cohort, with contribution of 8 inbred mouse strains backcrossed to C57BL/10.Q. Serum samples were collected from 1,640 mice before arthritis onset and at the peak of the disease. Antibody concentrations were measured by standard enzyme-linked immunosorbent assay, and linkage analysis was performed using a linear regression-based method. RESULTS: We identified loci controlling formation of anti-CII of different IgG isotypes (IgG1, IgG3), antibodies to major CII epitopes (C1, J1, U1), antibodies to a citrullinated CII peptide (citC1), and RF. The anti-CII, ACPA, and RF responses were all found to be controlled by distinct genes, one of the most important loci being the immunoglobulin heavy chain locus. CONCLUSION: This comprehensive genetic analysis of autoantibody formation in CIA demonstrates an association not only of anti-CII, but interestingly also of ACPA and RF, with arthritis development in mice. These results underscore the importance of non-major histocompatibility complex genes in controlling the formation of clinically relevant autoantibodies.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Raposo, B.Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
(författare)
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Ekman, D.Karolinska Institutet, Stockholm, Sweden
(författare)
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Klaczkowska, D.Karolinska Institutet, Stockholm, Sweden
(författare)
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Popovic, M.Karolinska Institutet, Stockholm, Sweden
(författare)
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Nandakumar, Kutty Selva,1965-Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden(Swepub:hh)kutnam
(författare)
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Lindvall, ThereseLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)infl-tli
(författare)
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Hultqvist, MalinLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)infl-mhu
(författare)
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Teneva, IvankaLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)med-itv
(författare)
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Johannesson, M.Karolinska Institutet,Karolinska Institutet, Stockholm, Sweden
(författare)
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Ahlqvist, EmmaLund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Lund University, Lund, Sweden(Swepub:lu)infl-eah
(författare)
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Holmdahl, RikardKarolinska Institutet,Lund University,Lunds universitet,Immunologi,Forskargrupper vid Lunds universitet,Immunology,Lund University Research Groups,Karolinska Institutet, Stockholm, Sweden(Swepub:lu)infl-rho
(författare)
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Karolinska InstitutetKarolinska Institutet, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:Arthritis and Rheumatism: Wiley710004-35911529-0131
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Ingår i:JOURNAL OF IMMUNOLOGY: Wiley710022-1767
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Ingår i:ANNALS OF THE RHEUMATIC DISEASES: Wiley710003-49671468-2060
Internetlänk
Hitta via bibliotek
Till lärosätets databas
- Av författaren/redakt...
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Forster, M.
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Raposo, B.
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Ekman, D.
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Klaczkowska, D.
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Popovic, M.
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Nandakumar, Kutt ...
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visa fler...
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Lindvall, Theres ...
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Hultqvist, Malin
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Teneva, Ivanka
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Johannesson, M.
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Ahlqvist, Emma
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Holmdahl, Rikard
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visa färre...
- Om ämnet
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- MEDICIN OCH HÄLSOVETENSKAP
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MEDICIN OCH HÄLS ...
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och Klinisk medicin
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och Reumatologi och ...
- Artiklar i publikationen
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Arthritis and Rh ...
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JOURNAL OF IMMUN ...
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ANNALS OF THE RH ...
- Av lärosätet
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Högskolan i Halmstad
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Lunds universitet
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Karolinska Institutet