Sex‐specific growth and lifespan effects of germline removal in the dioecious nematode Caenorhabditis remanei

Lind, Martin I., Dr, 1980- (författare): Högskolan i Halmstad,Akademin för företagande, innovation och hållbarhet,Uppsala University, Uppsala, Sweden

Mautz, Brian S. (författare): Uppsala University, Uppsala, Sweden; Johnson & Johnson, Spring House, Pennsylvania, USA

Carlsson, Hanne (författare): Uppsala University, Uppsala, Sweden; University of East Anglia, Norwich, United Kingdom

Maklakov, Alexei A. (författare): Animal Ecology, Department of Ecology and Genetics Uppsala University Uppsala Sweden;School of Biological Sciences University of East Anglia Norwich UK

(creator_code:org_t)

2024
2024
Engelska.
Ingår i: Aging Cell. - Chichester : Wiley-Blackwell. - 1474-9718 .- 1474-9726.

Relaterad länk:: https://doi.org/10.1...; visa fler...; https://urn.kb.se/re...; https://doi.org/10.1...; visa färre...

Abstract Ämnesord

Stäng

Germline regulates the expression of life-history traits and mediates the trade-off between reproduction and somatic maintenance. However, germline maintenance in itself can be costly, and the costs can vary between the sexes depending on the number of gametes produced across the lifetime. We tested this directly by germline ablation using glp-1 RNA interference (RNAi) in a dioecious nematode Caenorhabditis remanei. Germline removal strongly increased heat-shock resistance in both sexes, thus confirming the role of the germline in regulating somatic maintenance. However, germline removal resulted in increased lifespan only in males. High costs of mating strongly reduced lifespan in both sexes and obliterated the survival benefit of germline-less males even though neither sex produced any offspring. Furthermore, germline removal reduced male growth before maturation but not in adulthood, while female growth rate was reduced both before and especially after maturation. Thus, germline removal improves male lifespan without major growth costs, while germline-less females grow slower and do not live longer than reproductively functional counterparts in the absence of environmental stress. Overall, these results suggest that germline maintenance is costlier for males than for females in C. remanei. © 2024 The Author(s). Aging Cell published by Anatomical Society and John Wiley & Sons Ltd.

Av författaren/redakt...: Lind, Martin I., ...; Mautz, Brian S.; Carlsson, Hanne; Hinas, Andrea; Gudmunds, Erik; Maklakov, Alexei ...

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