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Gene expression pro...
Gene expression profiling in persons with multiple chemical sensitivity before and after a controlled n-butanol exposure session
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- Dantoft, Thomas M. (författare)
- Danish Research Centre for Chemical Sensitivities, Copenhagen University Hospital, Gentofte, Denmark; Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark; Research Centre for Prevention and Health, Copenhagen, Denmark
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- Skovbjerg, Sine (författare)
- Research Centre for Prevention and Health, Copenhagen, Denmark
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- Andersson, Linus, 1979- (författare)
- Umeå universitet,Högskolan i Gävle,Arbetshälsovetenskap,Centrum för belastningsskadeforskning,Department of Psychology, Umeå University, Umeå, Sweden,Institutionen för psykologi,Department of Occupational and Public Health Sciences, University of Gävle, Sweden
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- Claeson, Anna-Sara (författare)
- Umeå universitet,Institutionen för psykologi,Department of Psychology, Umeå University, Umeå, Sweden
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- Engkilde, Kaare (författare)
- Department of Dermato-Allergology, National Allergy Research Center, Copenhagen University Hospital Gentofte, Denmark
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- Lind, Nina (författare)
- Swedish University of Agricultural Sciences,Sveriges lantbruksuniversitet,Umeå universitet,Institutionen för psykologi,Department of Psychology, Umeå University, Umeå, Sweden; Department of Economics, Swedish University of Agricultural Sciences, Uppsala, Sweden,Institutionen för ekonomi,Department of Economics,Umeå University
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- Nordin, Steven (författare)
- Umeå universitet,Institutionen för psykologi,Department of Psychology, Umeå University, Umeå, Sweden
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- Hellgren, Lars I. (författare)
- Department of Biotechnology and Biomedicine, Technical University of Denmark, Lyngby, Denmark
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(creator_code:org_t)
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- 2017-02-22
- 2017
- Engelska.
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Ingår i: BMJ Open. - : BMJ. - 2044-6055. ; 7:2
- Relaterad länk:
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https://doi.org/10.1...
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https://bmjopen.bmj....
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https://umu.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://res.slu.se/i...
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Abstract
Ämnesord
Stäng
- OBJECTIVES: To investigate the pathophysiological pathways leading to symptoms elicitation in multiple chemical sensitivity (MCS) by comparing gene expression in MCS participants and healthy controls before and after a chemical exposure optimised to cause symptoms among MCS participants.The first hypothesis was that unexposed and symptom-free MCS participants have similar gene expression patterns to controls and a second hypothesis that MCS participants can be separated from controls based on differential gene expression upon a controlled n-butanol exposure.DESIGN: Participants were exposed to 3.7 ppm n-butanol while seated in a windowed exposure chamber for 60 min. A total of 26 genes involved in biochemical pathways found in the literature have been proposed to play a role in the pathogenesis of MCS and other functional somatic syndromes were selected. Expression levels were compared between MCS and controls before, within 15 min after being exposed to and 4 hours after the exposure.SETTINGS: Participants suffering from MCS and healthy controls were recruited through advertisement at public places and in a local newspaper.PARTICIPANTS: 36 participants who considered themselves sensitive were prescreened for eligibility. 18 sensitive persons fulfilling the criteria for MCS were enrolled together with 18 healthy controls.OUTCOME MEASURES: 17 genes showed sufficient transcriptional level for analysis. Group comparisons were conducted for each gene at the 3 times points and for the computed area under the curve (AUC) expression levels.RESULTS: MCS participants and controls displayed similar gene expression levels both at baseline and after the exposure and the computed AUC values were likewise comparable between the 2 groups. The intragroup variation in expression levels among MCS participants was noticeably greater than the controls.CONCLUSIONS: MCS participants and controls have similar gene expression levels at baseline and it was not possible to separate MCS participants from controls based on gene expression measured after the exposure.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology (hsv//eng)
- SAMHÄLLSVETENSKAP -- Psykologi -- Psykologi (hsv//swe)
- SOCIAL SCIENCES -- Psychology -- Psychology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Arbetsmedicin och miljömedicin (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Occupational Health and Environmental Health (hsv//eng)
Nyckelord
- Chemical exposure
- Exposure chamber
- Gene expression
- Multiple Chemical Sensitivity
- qPCR
- no Strategic Research Area (SFO)
- inget Strategiskt forskningsområde (SFO)
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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