Sökning: onr:"swepub:oai:DiVA.org:hik-942" >
Cellular receptor interactions of C-cluster human group A coxsackieviruses.
-
- Newcombe, Nicole G (författare)
- University of Newcastle
-
- Andersson, Per (författare)
- Högskolan i Kalmar,Naturvetenskapliga institutionen
-
- Johansson, E Susanne (författare)
- University of Newcastle
-
visa fler...
-
- Au, Gough G (författare)
- University of Newcastle
-
- Lindberg, A. Michael (författare)
- Högskolan i Kalmar,Naturvetenskapliga institutionen
-
- Barry, Richard D (författare)
- University of Newcastle
-
- Shafren, Darren R (författare)
- University of Newcastle
-
visa färre...
-
(creator_code:org_t)
- London : Society for General Microbiology, 2003
- Engelska.
-
Ingår i: Journal of General Virology. - London : Society for General Microbiology. - 0022-1317 .- 1465-2099. ; 84:Pt 11, s. 3041-3050
- Relaterad länk:
-
http://vir.sgmjourna...
-
visa fler...
-
https://doi.org/10.1...
-
https://urn.kb.se/re...
-
https://doi.org/10.1...
-
visa färre...
Abstract
Ämnesord
Stäng
- The cellular receptor complex of coxsackievirus A21 (CVA21), a C-cluster human enterovirus, is formed by the subtle interaction of individual cellular receptors, decay accelerating factor (DAF) and intercellular adhesion molecule-1 (ICAM-1). In this receptor complex, DAF functions in the membrane sequestration of the virus, while the role of ICAM-1 is as the functional cellular internalization receptor. However, despite the elucidation of the CVA21-cell receptor interactions, there have been few definite investigations into cellular receptor usage of other coxsackie A viruses (CVAs) belonging to the C-cluster. In the present study, radiolabelled virus-binding assays demonstrated that CVA13, -15, -18 and -20, a subset of the human enterovirus C-cluster, bind directly to surface-expressed ICAM-1, but not to surface-expressed DAF. Furthermore, lytic infection of ICAM-1-expressing rhabdomyosarcoma (RD) cells by this C-cluster subset of viruses was inhibited by specific ICAM-1 monoclonal antibody blockade, except for that of CVA20. Despite possessing ICAM-1-binding capabilities, CVA20 employed an as yet unidentified internalization receptor for cell entry and subsequent productive lytic infection of ICAM-1-negative RD cells. In a further example of C-cluster cellular receptor heterogeneity, CVA13 exhibited significant binding to the surface of CHO cells expressing neither DAF nor ICAM-1. Despite a common receptor usage of ICAM-1 by this subset of C-cluster CVAs, the amino acid residues postulated to represent the ICAM-1-receptor footprint were not conserved.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Mikrobiologi inom det medicinska området (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Microbiology in the medical area (hsv//eng)
Nyckelord
- Virology
- Virologi
- Virologi
- Virology
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)