Sökning: onr:"swepub:oai:DiVA.org:his-10438" >
Clinical manifestat...
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Browall, SarahKarolinska Institutet,Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
(författare)
Clinical manifestations of invasive pneumococcal disease by vaccine and non-vaccine types
- Artikel/kapitelEngelska2014
Förlag, utgivningsår, omfång ...
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2014-10-16
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European Respiratory Society,2014
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:his-10438
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-10438URI
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https://doi.org/10.1183/09031936.00080814DOI
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https://gup.ub.gu.se/publication/204625URI
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http://kipublications.ki.se/Default.aspx?queryparsed=id:130392113URI
Kompletterande språkuppgifter
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Språk:engelska
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Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Pneumococcal conjugated vaccines (PCVs) have shown protection against invasive pneumococcal disease by vaccine serotypes, but an increase in non-vaccine serotype disease has been observed. Type-specific effects on clinical manifestation need to be explored.Clinical data from 2096 adults and 192 children with invasive pneumococcal disease were correlated to pneumococcal molecular serotypes. Invasive disease potential for pneumococcal serotypes were calculated using 165 invasive and 550 carriage isolates from children.The invasive disease potential was lower for non-PCV13 compared to vaccine-type strains. Patients infected with non-PCV13 strains had more underlying diseases, were less likely to have pneumonia and, in adults, tended to have a higher mortality. Furthermore, patients infected with pneumococci belonging to clonal serotypes only expressing non-PCV13 capsules had a higher risk for septicaemia and mortality.PCV vaccination will probably lead to a decrease in invasive pneumococcal disease but an alteration in the clinical manifestation of invasive pneumococcal disease. Genetic lineages causing invasive pneumococcal disease in adults often express non-vaccine serotypes, which can expand after vaccination with an increased risk of infection in patients with underlying diseases.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
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Backhaus, ErikDepartment of Infectious Diseases, Skaraborg Hospital, Skövde, Sweden
(författare)
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Naucler, PontusKarolinska Institutet,Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden / Department of Infectious Diseases, Karolinska University Hospital, Solna, Sweden
(författare)
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Galanis, IliasDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
(författare)
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Sjöström, KarinDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
(författare)
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Karlsson, Diana,1975-Högskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Infektionsbiologi, Infection Biology(Swepub:his)kald
(författare)
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Berg, Stefan,1959Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:gu)xbeste
(författare)
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Luthander, JoachimKarolinska Institutet,Department of Paediatrics, Karolinska University Hospital, Solna, Sweden
(författare)
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Eriksson, MargaretaDepartment of Paediatrics, Karolinska University Hospital, Solna, Sweden
(författare)
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Spindler, CarlKarolinska Institutet,Department of Infectious Diseases, Karolinska University Hospital, Solna, Sweden
(författare)
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Ejdebäck, MikaelHögskolan i Skövde,Institutionen för biovetenskap,Forskningscentrum för Systembiologi,Infektionsbiologi, Infection Biology(Swepub:his)ejdm
(författare)
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Trollfors, Birger,1947Queen Silvia Children’s Hospital, Sahlgrenska University Hospital, Gothenburg, Sweden(Swepub:gu)xtrobi
(författare)
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Darenberg, JessicaPublic Health Agency of Sweden, Solna, Sweden
(författare)
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Kalin, MatsKarolinska Institutet,Department of Infectious Diseases, Karolinska University Hospital, Solna, Sweden
(författare)
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Örtqvist, ÅkeKarolinska Institutet,Department of Communicable Diseases Control and Prevention, Stockholm County Council, Stockholm, Sweden / Department of Medicine, Unit of Infectious Diseases, Karolinska Institutet, Solna, Sweden
(författare)
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Andersson, Rune,1951Gothenburg University,Göteborgs universitet,Institutionen för biomedicin, avdelningen för infektionssjukdomar,Institute of Biomedicine, Department of Infectious Medicine,Department of Infectious Diseases, Institute of Biomedicine, Sahlgrenska Academy, Gothenburg University, Gothenburg, Sweden(Swepub:gu)xandru
(författare)
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Henriques-Normark, BirgittaKarolinska Institutet,Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden Dept of Clinical Microbiology, Karolinska University Hospital, Stockholm, Sweden
(författare)
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Karolinska InstitutetDepartment of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:European Respiratory Journal: European Respiratory Society44:6, s. 1646-16570903-19361399-3003
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Till lärosätets databas
- Av författaren/redakt...
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Browall, Sarah
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Backhaus, Erik
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Naucler, Pontus
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Galanis, Ilias
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Sjöström, Karin
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Karlsson, Diana, ...
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visa fler...
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Berg, Stefan, 19 ...
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Luthander, Joach ...
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Eriksson, Margar ...
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Spindler, Carl
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Ejdebäck, Mikael
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Trollfors, Birge ...
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Darenberg, Jessi ...
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Kalin, Mats
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Örtqvist, Åke
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Andersson, Rune, ...
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Henriques-Normar ...
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