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  • Badam, TejaswiLinköpings universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Bioinformatics Department of Physics, Chemistry and Biology, Linköping University, Sweden,Translationell bioinformatik, Translational Bioinformatics,Bioinformatik,Tekniska fakulteten,Skovde Univ, Sweden (författare)

CD4(+) T-cell DNA methylation changes during pregnancy significantly correlate with disease-associated methylation changes in autoimmune diseases

  • Artikel/kapitelEngelska2022

Förlag, utgivningsår, omfång ...

  • 2021-10-04
  • Taylor & Francis Group,2022
  • electronicrdacarrier

Nummerbeteckningar

  • LIBRIS-ID:oai:DiVA.org:his-20648
  • https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-20648URI
  • https://doi.org/10.1080/15592294.2021.1982510DOI
  • http://kipublications.ki.se/Default.aspx?queryparsed=id:147800399URI
  • https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-180368URI

Kompletterande språkuppgifter

  • Språk:engelska
  • Sammanfattning på:engelska

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  • Ämneskategori:ref swepub-contenttype
  • Ämneskategori:art swepub-publicationtype

Anmärkningar

  • CC BY 4.0Contact Sandra Hellberg Email iconsandra.hellberg@liu.sePublished online: 04 Oct 2021Copyright © 2022 Informa UK Limited This work was supported by the Swedish Foundation for Strategic Research (SB16-0011), Swedish Research Council (K2013-61X-22310-01-4, 2015-030807, 2018-02776) and Lions research grant (Liu-2012-01948).
  • Funding Agencies|Swedish Foundation for Strategic ResearchSwedish Foundation for Strategic Research [SB16-0011]; Swedish Research CouncilSwedish Research CouncilEuropean Commission [K2013-61X-22310-01-4, 2015-030807, 2018-02776]; Lions research grant [Liu-2012-01948]
  • Epigenetics may play a central, yet unexplored, role in the profound changes that the maternal immune system undergoes during pregnancy and could be involved in the pregnancy-induced modulation of several autoimmune diseases. We investigated changes in the methylome in isolated circulating CD4(+) T-cells in non-pregnant and pregnant women, during the 1(st) and 2(nd) trimester, using the Illumina Infinium Human Methylation 450K array, and explored how these changes were related to autoimmune diseases that are known to be affected during pregnancy. Pregnancy was associated with several hundreds of methylation differences, particularly during the 2(nd) trimester. A network-based modular approach identified several genes, e.g., CD28, FYN, VAV1 and pathways related to T-cell signalling and activation, highlighting T-cell regulation as a central component of the observed methylation alterations. The identified pregnancy module was significantly enriched for disease-associated methylation changes related to multiple sclerosis, rheumatoid arthritis and systemic lupus erythematosus. A negative correlation between pregnancy-associated methylation changes and disease-associated changes was found for multiple sclerosis and rheumatoid arthritis, diseases that are known to improve during pregnancy whereas a positive correlation was found for systemic lupus erythematosus, a disease that instead worsens during pregnancy. Thus, the directionality of the observed changes is in line with the previously observed effect of pregnancy on disease activity. Our systems medicine approach supports the importance of the methylome in immune regulation of T-cells during pregnancy. Our findings highlight the relevance of using pregnancy as a model for understanding and identifying disease-related mechanisms involved in the modulation of autoimmune diseases.

Ämnesord och genrebeteckningar

Biuppslag (personer, institutioner, konferenser, titlar ...)

  • Hellberg, SandraLinköpings universitet,Bioinformatik,Tekniska fakulteten(Swepub:liu)sanhe13 (författare)
  • Bhai Mehta, RatneshLinköpings universitet,Karolinska Institutet,Division of Inflammation and Infection, Department of Biomedical and Clinical Sciences, Linköping University, Sweden,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)ratme61 (författare)
  • Lechner-Scott, JeannetteSchool of Medicine and Public Health, University of Newcastle, Callaghan, Australia ; Centre for Brain and Mental Health, Hunter Medical Research Institute, New Lambton Heights, Australia ; Department of Neurology, John Hunter Hospital, New Lambton Heights, Australia,Univ Newcastle, Australia; Hunter Med Res Inst, Australia; John Hunter Hosp, Australia (författare)
  • Lea, Rodney A.School of Medicine and Public Health, University of Newcastle, Callaghan, Australia ; Centre for Brain and Mental Health, Hunter Medical Research Institute, New Lambton Heights, Australia ; Institute of Health and Biomedical Innovations, Genomics Research Centre, Queensland University of Technology, Kelvin Grove, Australia,Univ Newcastle, Australia; Hunter Med Res Inst, Australia; Queensland Univ Technol, Australia (författare)
  • Tost, JorgLaboratory of Epigenetics and Environment, Centre National De Recherche En Génomique Humaine, CEA-Institut De Biologie Francois Jacob, Evry, France,CEA Inst Biol Francois Jacob, France (författare)
  • Mariette, XavierUniversité Paris-Saclay, AP-HP-Université Paris-Saclay, Hôpital Bicêtre, Institut National de la Santé et de la Recherche Médicale (Inserm) U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, France,Univ Paris Saclay, France (författare)
  • Svensson-Arvelund, Judit,1982-Linköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)judsv82 (författare)
  • Nestor, ColmLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten(Swepub:liu)colne37 (författare)
  • Benson, MikaelLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, H.K.H. Kronprinsessan Victorias barn- och ungdomssjukhus(Swepub:liu)mikbe05 (författare)
  • Berg, GöranLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten,Region Östergötland, Kvinnokliniken US(Swepub:liu)gorbe09 (författare)
  • Jenmalm, MariaLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten(Swepub:liu)marje18 (författare)
  • Gustafsson, MikaLinköpings universitet,Bioinformatik,Tekniska fakulteten(Swepub:liu)mikgu75 (författare)
  • Ernerudh, JanLinköpings universitet,Avdelningen för inflammation och infektion,Medicinska fakulteten,Region Östergötland, Klinisk immunologi och transfusionsmedicin(Swepub:liu)janer15 (författare)
  • Högskolan i SkövdeInstitutionen för biovetenskap (creator_code:org_t)

Sammanhörande titlar

  • Ingår i:Epigenetics: Taylor & Francis Group17:9, s. 1040-10551559-22941559-2308

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