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Manipulations of Or...
Manipulations of Oral Medications in Paediatric Neurology and Oncology Care at a Swedish University Hospital : Health Professionals' Attitudes and Sources of Information
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- Kader, Rania (författare)
- Uppsala universitet,Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Department of Women’s and Children’s Health, Uppsala University, Sweden ; Division of Pharmacokinetics and Drug Therapy, Department of Pharmaceutical Biosciences, Uppsala University, Sweden,Translationell medicin (TRIM),Barnneurologi/Barnonkologi,Institutionen för farmaceutisk biovetenskap
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- Liminga, Gunnar (författare)
- Uppsala universitet,Barnneurologi/Barnonkologi
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- Ljungman, Gustaf, 1958- (författare)
- Uppsala universitet,Barnneurologi/Barnonkologi
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- Paulsson, Mattias (författare)
- Uppsala universitet,Barnneurologi/Barnonkologi
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(creator_code:org_t)
- 2021-10-13
- 2021
- Engelska.
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Ingår i: Pharmaceutics. - : MDPI. - 1999-4923. ; 13:10
- Relaterad länk:
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https://doi.org/10.3...
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https://his.diva-por... (primary) (Raw object)
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https://www.mdpi.com...
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https://uu.diva-port... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.3...
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https://urn.kb.se/re...
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Abstract
Ämnesord
Stäng
- Oral administration of medications to children requires age-appropriate dosage forms and strengths. In this study, we: (i) assessed the extent of oral dosage form manipulations, (ii) documented how it is carried out, and (iii) examined the attitudes and sources of information regarding the handling from healthcare professionals. Prospective reviews of electronic records, ward observations, and clinician surveys were performed at a paediatric neurology ward and a paediatric oncology ward in Sweden during April to May of 2018. Approximately 15% of oral medications were manipulated for the studied patient group (median age 12.9 years in oncology, 5.8 years in neurology) with approximately 30% of the patients having an enteral feeding tube. Manipulations were performed both to obtain an appropriate dose from, for example, a fraction of the original tablet or to obtain a powder that could be used to prepare a slurry for administration through enteral feeding tubes. Risks identified were related to patient safety such as cross contamination, suboptimal absorption/pharmacokinetics and inaccurate dose. When examining the working environment of nurses, we observed safe handling of hazardous substances but the nurses occasionally experienced stress and a fear of making mistakes due to absence of information. Paediatricians experienced a lack of time to search for proper information on manipulations. As a step towards improving safety in paediatric medication, we suggest the introduction of clinical pharmacists into the team and further evaluating the possibilities of using more ready-to-administer medications with necessary product information and pharmacovigilance support.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmaceutiska vetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmaceutical Sciences (hsv//eng)
Nyckelord
- paediatrics
- children
- manipulation
- oral medication
- patient safety
- survey
- health care professionals' attitude
- enteral feeding tubes
- pharmacoprinting
- Translationell medicin TRIM
- Translational Medicine TRIM
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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