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Transcriptional Res...
Transcriptional Responses as Biomarkers of General Toxicity : A Systematic Review and Meta-Analysis on Metal-Exposed Bivalves
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- Ekelund Ugge, Gustaf Magnus Oskar (författare)
- University of Skövde,Lund University,Lunds universitet,Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Department of Biology, Lund University, Sweden,Ekologisk modellering, Ecological modelling,Enhet akvatisk ekologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Akvatisk ekologi,Forskargrupper vid Lunds universitet,Division aquatic ecology,Faculty of Science,Aquatic Ecology,Lund University Research Groups
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- Sahlin, Ullrika (författare)
- Lund University,Lunds universitet,Centrum för miljö- och klimatvetenskap (CEC),Naturvetenskapliga fakulteten,Beräkningsvetenskap för hälsa och miljö,Forskargrupper vid Lunds universitet,Centre for Environmental and Climate Science (CEC),Faculty of Science,Computational Science for Health and Environment,Lund University Research Groups
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- Jonsson, Annie (författare)
- University of Skövde,Högskolan i Skövde,Institutionen för biovetenskap,Forskningsmiljön Systembiologi,Ekologisk modellering, Ecological modelling
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- Berglund, Olof (författare)
- Lund University,Lunds universitet,Enhet akvatisk ekologi,Biologiska institutionen,Naturvetenskapliga fakulteten,Akvatisk ekologi,Forskargrupper vid Lunds universitet,Division aquatic ecology,Department of Biology,Faculty of Science,Aquatic Ecology,Lund University Research Groups
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(creator_code:org_t)
- 2023-02-10
- 2023
- Engelska.
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Ingår i: Environmental Toxicology and Chemistry. - : John Wiley & Sons. - 0730-7268 .- 1552-8618. ; 42:3, s. 628-641
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Abstract
Ämnesord
Stäng
- Through a systematic review and a series of meta-analyses, we evaluated the general responsiveness of putative transcriptional biomarkers of general toxicity and chemical stress. We targeted metal exposures performed on bivalves under controlled laboratory conditions, and selected six transcripts associated with general toxicity for evaluation: catalase (cat), glutathione-S-transferase (gst), heat shock proteins 70 and 90 (hsp70, hsp90), metallothionein (mt) and superoxide dismutase (sod). Transcriptional responses (n = 396) were extracted from published scientific articles (k = 22) and converted to log response ratios (lnRRs). By estimating toxic units (TUs), we normalized different metal exposures to a common scale, as a proxy of concentration. Using Bayesian hierarchical random effect models, we then tested the effects of metal exposure on lnRR, both for metal exposure in general and in meta-regressions using TU and exposure time as independent variables. Corresponding analyses were also repeated with transcript and tissue as additional moderators. Observed patterns were similar for general as for transcript- and tissue-specific responses. The expected overall response to arbitrary metal exposure was a lnRR of 0.50, corresponding to a 65 % increase relative a non-exposed control. However, when accounting for publication bias, the estimated ‘true’ response showed no such effect. Furthermore, expected response magnitude increased slightly with exposure time, but there was little support for general monotonic concentration-dependence with regards to TU. Altogether, this work reveals potential limitations that need consideration prior to applying the selected transcripts as biomarkers in environmental risk assessment. This article is protected by copyright. All rights reserved. Environ Toxicol Chem 2022;00:0–0.
Ämnesord
- NATURVETENSKAP -- Geovetenskap och miljövetenskap -- Miljövetenskap (hsv//swe)
- NATURAL SCIENCES -- Earth and Related Environmental Sciences -- Environmental Sciences (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Farmakologi och toxikologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Pharmacology and Toxicology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Biokemi och molekylärbiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Biochemistry and Molecular Biology (hsv//eng)
- NATURVETENSKAP -- Biologi -- Annan biologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Other Biological Topics (hsv//eng)
Nyckelord
- Chemical analysis
- Metals
- Molluscs
- Random processes
- Risk assessment
- Superoxide dismutase
- Tissue
- Toxicity
- Aquatic toxicology
- Bayesian statistics
- Eco-toxicology
- Meta-regression
- Metal exposures
- Mollusk toxicology
- Publication bias
- Risks assessments
- Toxic unit
- Transcriptional response
- Biomarkers
- ecotoxicology
- Ekologisk modellering
- Ecological Modelling Group
Publikations- och innehållstyp
- ref (ämneskategori)
- for (ämneskategori)
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