Sökning: onr:"swepub:oai:DiVA.org:his-22515" >
Human endogenous ox...
Human endogenous oxytocin and its neural correlates show adaptive responses to social touch based on recent social context
-
- Handlin, Linda, 1981- (författare)
- Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Translational Medicine TRIM
-
- Novembre, Giovanni (författare)
- Division of Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Sweden
-
- Lindholm, Heléne (författare)
- Högskolan i Skövde,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Translational Medicine TRIM
-
visa fler...
-
- Kämpe, Robin (författare)
- Center for Medical Image Science and Visualization (CMIV) Linköping University Hospital, Sweden ; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Sweden
-
- Paul, Elisabeth (författare)
- Center for Medical Image Science and Visualization (CMIV) Linköping University Hospital, Sweden ; Center for Social and Affective Neuroscience, Department of Biomedical and Clinical Sciences, Linköping University, Sweden
-
- Morrison, India (författare)
- Division of Neurobiology, Department of Biomedical and Clinical Sciences, Linköping University, Sweden ; Center for Medical Image Science and Visualization (CMIV) Linköping University Hospital, Sweden
-
visa färre...
-
(creator_code:org_t)
- eLife Sciences Publications Ltd, 2023
- 2023
- Engelska.
-
Ingår i: eLIFE. - : eLife Sciences Publications Ltd. - 2050-084X. ; 12
- Relaterad länk:
-
https://doi.org/10.7...
-
visa fler...
-
https://his.diva-por... (primary) (Raw object)
-
https://urn.kb.se/re...
-
https://doi.org/10.7...
-
visa färre...
Abstract
Ämnesord
Stäng
- Both oxytocin (OT) and touch are key mediators of social attachment. In rodents, tactile stimulation elicits endogenous release of OT, potentially facilitating attachment and other forms of prosocial behavior, yet the relationship between endogenous OT and neural modulation remains unexplored in humans. Using serial sampling of plasma hormone levels during functional neuroimaging across two successive social interactions, we show that contextual circumstances of social touch facilitate or inhibit not only current hormonal and brain responses, but also calibrate later responses. Namely, touch from a male to his female romantic partner enhanced subsequent OT release for touch from an unfamiliar stranger, yet OT responses to partner touch were dampened following stranger touch. Hypothalamus and dorsal raphe activation reflected plasma OT changes during the initial interaction. In thesubsequent social interaction, time- and context-dependent OT changes modulated precuneus and parietal-temporal cortex pathways, including a region of medial prefrontal cortex that also covaried with plasma cortisol. These findings demonstrate that hormonal neuromodulation during successive human social interactions is adaptive to social context, and point to mechanisms that flexibly calibrate receptivity in social encounters.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Medicinska och farmaceutiska grundvetenskaper -- Neurovetenskaper (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Basic Medicine -- Neurosciences (hsv//eng)
Nyckelord
- Translationell medicin TRIM
- Translational Medicine TRIM
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
Hitta via bibliotek
-
eLIFE
(Sök värdpublikationen i LIBRIS)
Till lärosätets databas