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NF-kappa B p65 phos...
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Lewander, AndreasLinköpings universitet,Onkologi,Hälsouniversitetet
(författare)
NF-kappa B p65 phosphorylated at serine-536 is an independent prognostic factor in Swedish colorectal cancer patients
- Artikel/kapitelEngelska2012
Förlag, utgivningsår, omfång ...
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2011-11-22
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Springer,2012
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printrdacarrier
Nummerbeteckningar
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LIBRIS-ID:oai:DiVA.org:his-5692
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https://urn.kb.se/resolve?urn=urn:nbn:se:his:diva-5692URI
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https://doi.org/10.1007/s00384-011-1356-8DOI
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https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-76610URI
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Språk:engelska
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Sammanfattning på:engelska
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Ämneskategori:ref swepub-contenttype
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Ämneskategori:art swepub-publicationtype
Anmärkningar
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Funding Agencies|Swedish Cancer Foundation||Swedish Research Council||Health Research Council in the Southeast of Sweden||
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The NF-kappa B transcription factor protein family has diverse cellular and biological functions, and posttranslational modification is important to regulate these functions. An important site of phosphorylation of NF-kappa B p65 subunit is at serine-536 (phospho-Ser536-p65), and this phosphorylation is involved in regulation of transcriptional activity, nuclear localization, and protein stability. In this study, we investigated expression of phospho-Ser536-p65 in colorectal cancers and its relationships with clinicopathological factors. The expression of phospho-Ser536-p65 was examined by immunohistochemistry in 203 primary colorectal cancers, 156 normal mucosa specimens, and 18 metastases in the lymph nodes. The expression of phospho-Ser536-p65 increased from normal mucosa to primary tumor (p < 0.0001). Further, the increased expression of phospho-Ser536-p65 in the cytoplasm of the primary tumors correlated with worse survival of the patients independently of gender, age, tumor location, stage, and differentiation (p = 0.04; hazard ratio, 1.89; 95% CI 1.03-3.47). The NF-kappa B p65 subunit phosphorylated at serine-536 is an independent prognostic factor in colorectal cancer patients.
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Biuppslag (personer, institutioner, konferenser, titlar ...)
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Gao, JingfangLinköpings universitet,Onkologi,Hälsouniversitetet(Swepub:liu)jinga59
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Carstensen, JohnLinköpings universitet,Hälsa och samhälle,Hälsouniversitetet(Swepub:liu)johca98
(författare)
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Arbman, GunnarÖstergötlands Läns Landsting,Linköpings universitet,Kirurgi,Hälsouniversitetet,Kirurgiska kliniken ViN(Swepub:liu)gunar63
(författare)
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Zhang, HongHögskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi,Tumour Biology,University of Skövde(Swepub:his)zhah
(författare)
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Sun, Xiao-FengÖstergötlands Läns Landsting,Linköpings universitet,Onkologi,Hälsouniversitetet,Onkologiska kliniken US(Swepub:liu)xiasu45
(författare)
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Linköpings universitetOnkologi
(creator_code:org_t)
Sammanhörande titlar
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Ingår i:International Journal of Colorectal Disease: Springer27:4, s. 447-4520179-19581432-1262
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