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miHA-Match :
miHA-Match : Computational detection of tissue-specific minor histocompatibility antigens
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- Feldhahn, Magdalena (författare)
- University of Tübingen, Center for Bioinformatics, Applied Bioinformatics, Sand 14, 72076 Tübingen, Germany
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- Dönnes, Pierre (författare)
- Högskolan i Skövde,Institutionen för vård och natur,Forskningscentrum för Systembiologi
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- Schubert, Benjamin (författare)
- University of Tübingen, Center for Bioinformatics, Applied Bioinformatics, Sand 14, 72076 Tübingen, Germany
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- Schilbach, Karin (författare)
- University Children's Hospital, Department of, Hematology/Oncology, Hoppe-Seyler Str. 1, 72076, Tübingen, Germany
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- Rammensee, Hans-Georg (författare)
- University of Tübingen, Department of Immunology, Auf der Morgenstelle 15, 72076 Tuebingen, Germany
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- Kohlbacher, Oliver (författare)
- University of Tübingen, Center for Bioinformatics, Applied Bioinformatics, Sand 14, 72076 Tübingen, Germany / University of Tübingen, Quantitative Biology Center, Tübingen, Germany
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(creator_code:org_t)
- Elsevier, 2012
- 2012
- Engelska.
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Ingår i: JIM - Journal of Immunological Methods. - : Elsevier. - 0022-1759 .- 1872-7905. ; 386:1-2, s. 94-100
- Relaterad länk:
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https://urn.kb.se/re...
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Allogenic stem cell transplantation has shown considerable success in a number of hematological malignancies, in particular in leukemia. The beneficial effect is mediated by donor T cells recognizing patient-specific HLA-binding peptides. These peptides are called minor histocompatibility antigens (miHAs) and are typically caused by single nucleotide polymorphisms. Tissue-specific miHAs have successfully been used in anti-tumor therapy without causing unspecific graft-versus-host reactions. However, only a small number of miHAs have been identified to date, limiting the clinical use.Here we present an immunoinformatics pipeline for the identification of miHAs. The pipeline can be applied to large-scale miHA screening, for example, in the development of diagnostic tests. Another interesting application is the design of personalized miHA-based cancer therapies based on patient-donor pair-specific miHAs detected by this pipeline. The suggested method covers various aspects of genetic variant detection, effects of alternative transcripts, and HLA-peptide binding. A comparison of our computational pipeline and experimentally derived datasets shows excellent agreement and coverage of the computationally predicted miHAs.
Ämnesord
- NATURVETENSKAP -- Biologi -- Bioinformatik och systembiologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Bioinformatics and Systems Biology (hsv//eng)
Nyckelord
- Minor histocompatibility antigens
- Immunoinformatics
- Transplantation
- Natural sciences
- Naturvetenskap
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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