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Subjective cognitiv...
Subjective cognitive impairment subjects in our clinical practice
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- Garcia-Ptacek, Sara (författare)
- Karolinska Institutet
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- Cavallin, Lena (författare)
- Karolinska Institutet
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- Kåreholt, Ingemar (författare)
- Karolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi
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- Kramberger, Milica Gregoric (författare)
- Karolinska Institutet Alzheimer Disease Research Center, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Sweden
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- Winblad, Bengt (författare)
- Karolinska Institutet
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- Jelic, Vesna (författare)
- Karolinska Institutet
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- Eriksdotter, Maria (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2014-11-11
- 2014
- Engelska.
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Ingår i: Dementia and Geriatric Cognitive Disorders Extra. - : S. Karger AG. - 1664-5464. ; 4:3, s. 419-430
- Relaterad länk:
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https://doi.org/10.1...
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https://hj.diva-port... (primary) (Raw object)
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https://www.karger.c...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- BACKGROUND:The clinical challenge in subjective cognitive impairment (SCI) is to identify which individuals will present cognitive decline. We created a statistical model to determine which variables contribute to SCI and mild cognitive impairment (MCI) versus Alzheimer's disease (AD) diagnoses.METHODS:A total of 993 subjects diagnosed at a memory clinic (2007-2009) were included retrospectively: 433 with SCI, 373 with MCI and 187 with AD. Descriptive statistics were provided. A logistic regression model analyzed the likelihood of SCI and MCI patients being diagnosed with AD, using age, gender, Mini-Mental State Examination score, the ratio of β-amyloid 42 divided by total tau, and phosphorylated tau as independent variables.RESULTS:The SCI subjects were younger (57.8 ± 8 years) than the MCI (64.2 ± 10.6 years) and AD subjects (70.1 ± 9.7 years). They were more educated, had less medial temporal lobe atrophy (MTA) and frequently normal cerebrospinal fluid biomarkers. Apolipoprotein E4/E4 homozygotes and apolipoprotein E3/E4 heterozygotes were significantly less frequent in the SCI group (6 and 36%) than in the AD group (28 and 51%). Within the regression model, cardiovascular risk factors, confluent white matter lesions, MTA and central atrophy increased the AD likelihood for SCI subjects.CONCLUSIONS:SCI patients form a distinct group. In our model, factors suggesting cardiovascular risk, MTA and central atrophy increased the AD likelihood for SCI subjects.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- Alzheimer's disease; Dementia; Mild cognitive impairment
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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