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Impact of selenium ...
Impact of selenium status on the pathogenesis of mycobacterial disease in HIV-1-infected drug users during the era of highly active antiretroviral therapy
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- Shor-Posner, G. (författare)
- Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States
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- Miguez, M. J. (författare)
- Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States
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- Pineda, L. (författare)
- Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States
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visa fler...
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- Rodriguez, A. (författare)
- Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States
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- Ruiz, P. (författare)
- Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States
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- Castillo, G. (författare)
- Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States
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- Burbano, X. (författare)
- Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States
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- Lecusay, Robert (författare)
- Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States
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- Baum, M. (författare)
- Division of Disease Prevention, Department of Psychiatry, Miami, FL, United States
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visa färre...
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(creator_code:org_t)
- 2002
- 2002
- Engelska.
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Ingår i: Journal of Acquired Immune Deficiency Syndromes. - 1525-4135 .- 1944-7884. ; 29:2, s. 169-173
- Relaterad länk:
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https://urn.kb.se/re...
Abstract
Ämnesord
Stäng
- The risk of mycobacterial disease is significantly increased in drug abusers as well as in immunocompromised HIV-1-infected individuals. The essential trace element selenium has an important function in maintaining immune processes and may, thus, have a critical role in clearance of mycobacteria. The impact of selenium status on the development of mycobacterial diseases in HIV-1-seropositive drug users was investigated over a 2-year period (1999-2001). Twelve cases of mycobacterial disease (tuberculosis, 9; infection due to atypical Mycobacterium species, 3) occurred; these 12 cases were compared with 32 controls with no history of respiratory infections who were matched on age, sex, and HIV status. Significant risk for development of mycobacterial disease was associated with a CD4 cell count of <200/mm(3), malnutrition, and selenium levels of less than or equal to 135 mug/L (patients with these levels were 13 times more likely to develop mycobacterial disease). Multivariate analyses controlling for antiretroviral treatment and CD4 cell count revealed that both body mass index and selenium level remained significant factors in the relative risk for developing mycobacterial disease (relative risk, 3; p =.015); these findings suggest that selenium status may have a profound impact on the pathogenesis of mycobacterial disease.
Ämnesord
- NATURVETENSKAP -- Biologi -- Immunologi (hsv//swe)
- NATURAL SCIENCES -- Biological Sciences -- Immunology (hsv//eng)
Nyckelord
- tuberculosis
- selenium
- malnutrition
- drug users
- HIV/AIDS
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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