Sökning: onr:"swepub:oai:DiVA.org:hj-47189" >
Genetic polymorphis...
-
Dimberg, JanJönköping University,HHJ, Avdelningen för naturvetenskap och biomedicin,HHJ. Biomedicinsk plattform,Jonkoping Univ, Sweden
(författare)
Genetic polymorphism patterns suggest a genetic driven inflammatory response as pathogenesis in appendicitis
- Artikel/kapitelEngelska2020
Förlag, utgivningsår, omfång ...
-
2019-12-16
-
Springer,2020
-
printrdacarrier
Nummerbeteckningar
-
LIBRIS-ID:oai:DiVA.org:hj-47189
-
https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-47189URI
-
https://doi.org/10.1007/s00384-019-03473-1DOI
-
https://urn.kb.se/resolve?urn=urn:nbn:se:liu:diva-164048URI
Kompletterande språkuppgifter
-
Språk:engelska
-
Sammanfattning på:engelska
Ingår i deldatabas
Klassifikation
-
Ämneskategori:ref swepub-contenttype
-
Ämneskategori:art swepub-publicationtype
Anmärkningar
-
PURPOSE: The pathogenesis of appendicitis is not well understood. Environmental factors are regarded most important, but epidemiologic findings suggest a role of inflammatory and genetic mechanisms. This study determines the association of single nucleotide polymorphisms (SNPs) of inflammatory genes with appendicitis.METHODS: As part of a larger prospective study on the diagnostic value of inflammatory variables in appendicitis, the genotype frequency of 28 polymorphisms in 26 inflammatory response genes from the appendicitis and control patients was analyzed in blood samples from 343 patients, 100 with appendicitis, and 243 with non-specific abdominal pain, using TaqMan SNP genotyping assays.RESULTS: Associations with appendicitis were found for SNPs IL-13 rs1800925 with odds ratio (OR) 6.02 (95% CI 1.52-23.78) for T/T versus C/C + T/T, for IL-17 rs2275913 with OR 2.38 (CI 1.24-4.57) for A/A vs G/G + GA, for CCL22 rs223888 with OR 0.12 (0.02-0.90), and for A/A vs G/G + GA. Signs of effect modification of age for the association with appendicitis were found for IL-13 rs1800925 and CTLA4 rs3087243. Stratified analysis showed difference in association with severity of disease for IL-17 rs2275913 and CD44 rs187115.CONCLUSIONS: The association of gene variants on risk of appendicitis and its severity suggest an etiologic role of genetically regulated inflammatory response. This may have implications for understanding the prognosis of untreated appendicitis as a possible self-limiting disorder and for understanding the inverse association of appendicitis with ulcerative colitis.
Ämnesord och genrebeteckningar
Biuppslag (personer, institutioner, konferenser, titlar ...)
-
Rubér, MarieLinköpings universitet,Avdelningen för barns och kvinnors hälsa,Medicinska fakulteten(Swepub:liu)marru90
(författare)
-
Skarstedt, MaritaDepartment of Laboratory Medicine, Division of Clinical Microbiology, Region Jönköping County, Jönköping, Sweden,Dept Lab Med, Sweden
(författare)
-
Andersson, ManneLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Cty Hosp Ryhov, Sweden(Swepub:liu)manan92
(författare)
-
Andersson, RolandLinköpings universitet,Avdelningen för kirurgi, ortopedi och onkologi,Medicinska fakulteten,Cty Hosp Ryhov, Sweden(Swepub:liu)rolan90
(författare)
-
Jönköping UniversityHHJ, Avdelningen för naturvetenskap och biomedicin
(creator_code:org_t)
Sammanhörande titlar
-
Ingår i:International Journal of Colorectal Disease: Springer35, s. 277-2840179-19581432-1262
Internetlänk
Hitta via bibliotek
Till lärosätets databas