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Joint impact of com...
Joint impact of common risk factors on incident dementia : A cohort study of the Swedish Twin Registry
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- Tomata, Y. (författare)
- Karolinska Institutet
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- Li, X. (författare)
- Karolinska Institutet
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- Karlsson, Ida K. (författare)
- Karolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Mosing, M. A. (författare)
- Karolinska Institutet
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- Pedersen, N. L. (författare)
- Karolinska Institutet
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- Hägg, S. (författare)
- Karolinska Institutet
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(creator_code:org_t)
- 2020-05-03
- 2020
- Engelska.
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Ingår i: Journal of Internal Medicine. - : John Wiley & Sons. - 0954-6820 .- 1365-2796. ; 288:2, s. 234-247
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https://doi.org/10.1...
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Abstract
Ämnesord
Stäng
- Background: As common risk factors of dementia, nine factors (low education, hearing loss, obesity, hypertension, smoking, depression, physical inactivity, diabetes and social isolation) were proposed. However, the joint impact of these factors on incident dementia is still uncertain; hence, we aimed to examine this impact.Methods: We conducted a cohort study of 9017 cognitively intact individuals aged ≥ 65 years in the Swedish Twin Registry. The main exposure was the total number of reported risk factors (ranging from 0 to 9). Data on dementia diagnoses were based on clinical workup and national health registers. After estimating the adjusted hazard ratios of incident dementia, the population attributable fraction (PAF) was calculated. We then conducted additional analyses, including APOE ε4 status in a genotyped subsample (n = 2810) to check the relative impact of the main exposure and discordant twin pair (n = 1158) analysis to consider confounding by familial effects (shared genetic or familial environmental factors).Results: The number of dementia cases was 1950 (21.6%). A dose-response relationship between the number of risk factors and incident dementia was observed; hazard ratio (95% confidence interval) per one-unit increment in number of risk factors was 1.07 (1.03 to 1.11). The PAF for the combination of the nine risk factors was 10.4%. The PAF of all nine risk factors was smaller than that of APOE ε4 genotype (20.8%) in the subsample. Discordant pair analysis suggested that the observed association was not likely explained by familial effects.Conclusion: The nine risk factors may have considerable impact as modifiable factors on incident dementia.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- attributable fraction
- cohort
- dementia
- joint effect
- risk factors
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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