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Dementia risk in wo...
Dementia risk in women higher in same-sex than opposite-sex twins
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- Luo, Jing (författare)
- Univ Southern Calif, Dept Psychol, 3620 South McClintock Ave, Los Angeles, CA 90089 USA.
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- Beam, Christopher R. (författare)
- Univ Southern Calif, Dept Psychol, 3620 South McClintock Ave, Los Angeles, CA 90089 USA.;Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA.
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- Karlsson, Ida K. (författare)
- Karolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.
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- Pike, Christian J. (författare)
- Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA.
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- Reynolds, Chandra A. (författare)
- Univ Calif Riverside, Dept Psychol, Riverside, CA 92521 USA.
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- Gatz, Margaret (författare)
- Univ Southern Calif, Dept Psychol, 3620 South McClintock Ave, Los Angeles, CA 90089 USA.;Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA.;Karolinska Inst, Dept Med Epidemiol & Biostat, Stockholm, Sweden.;Univ Southern Calif, Ctr Econ & Social Res, Los Angeles, CA 90089 USA.
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Univ Southern Calif, Dept Psychol, 3620 South McClintock Ave, Los Angeles, CA 90089 USA Univ Southern Calif, Dept Psychol, 3620 South McClintock Ave, Los Angeles, CA 90089 USA.;Univ Southern Calif, Leonard Davis Sch Gerontol, Los Angeles, CA 90089 USA. (creator_code:org_t)
- 2020-06-21
- 2020
- Engelska.
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Ingår i: Alzheimer's & Dementia: Diagnosis, Assessment & Disease Monitoring. - : John Wiley & Sons. - 2352-8729. ; 12:1
- Relaterad länk:
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https://doi.org/10.1...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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https://doi.org/10.1...
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http://kipublication...
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Abstract
Ämnesord
Stäng
- IntroductionHormones may be one possible mechanism underlying sex differences in dementia incidence. We examined whether presumed differential prenatal hormone milieu is related to dementia risk by comparing dementia rates in same- and opposite-sex dizygotic twin pairs in male and female twins.MethodsThe sample comprised 43,254 individuals from dizygotic twin pairs aged 60 and older from the Swedish Twin Registry. Survival analyses were conducted separately for females and males.ResultsFemale twins from opposite-sex pairs had significantly lower dementia risk than female twins from same-sex pairs, but the differences emerged only after age 70 (hazard ratio = 0.64, P = 0.004). Results were not explained by postnatal risk factors for dementia, and no interaction between twin type and apolipoprotein E (APOE) epsilon 4 was found. Male twins from same-sex versus opposite-sex pairs did not differ significantly.DiscussionThe results suggest that relatively masculine prenatal hormone milieus correlate with lower dementia risk in females.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Psykiatri (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Psychiatry (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
Nyckelord
- apolipoprotein E4
- dementia
- sex differences
- testosterone
- twin study
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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