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Independent and joi...
Independent and joint effects of body mass index and metabolic health in mid- and late-life on all-cause mortality : a cohort study from the Swedish Twin Registry with a mean follow-up of 13 Years
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- Ler, Peggy (författare)
- Jönköping University,HHJ. ARN-J (Aging Research Network - Jönköping),The Jönköping Academy for Improvement of Health and Welfare,Aging Research Network-Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Sweden
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- Li, X. (författare)
- Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Hassing, Linda, 1967 (författare)
- Gothenburg University,Göteborgs universitet,Centrum för åldrande och hälsa (AgeCap),Psykologiska institutionen,Centre for Ageing and Health (Agecap),Department of Psychology
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- Reynolds, C. A. (författare)
- Department of Psychology, University of California - Riverside, Riverside, CA, USA
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- Finkel, Deborah (författare)
- Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Aging Research Network-Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Sweden ; Department of Psychology, Indiana University Southeast, New Albany, IN, United States
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- Karlsson, Ida K. (författare)
- Karolinska Institutet,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),Aging Research Network-Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Sweden ; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden
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- Dahl Aslan, Anna K., 1975- (författare)
- Karolinska Institutet,Högskolan i Skövde,Jönköping University,HHJ, Institutet för gerontologi,HHJ. ARN-J (Aging Research Network - Jönköping),School of Health Sciences, University of Skövde, Sweden,Institutionen för hälsovetenskaper,Forskningsmiljön hälsa, hållbarhet och digitalisering,Aging Research Network-Jönköping (ARN-J), School of Health and Welfare, Jönköping University, Sweden ; Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden,Välbefinnande vid långvariga hälsoproblem (WeLHP), Wellbeing in long-term health problems (WeLHP)
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Jönköping University HHJ ARN-J (Aging Research Network - Jönköping) (creator_code:org_t)
- 2022-04-11
- 2022
- Engelska.
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Ingår i: BMC Public Health. - : Springer. - 1471-2458. ; 22:1
- Relaterad länk:
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https://doi.org/10.1...
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https://his.diva-por... (primary) (Raw object)
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https://urn.kb.se/re...
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https://doi.org/10.1...
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https://urn.kb.se/re...
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http://kipublication...
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https://gup.ub.gu.se...
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Abstract
Ämnesord
Stäng
- BACKGROUND: There is robust evidence that in midlife, higher body mass index (BMI) and metabolic syndrome (MetS), which often co-exist, are associated with increased mortality risk. However, late-life findings are inconclusive, and few studies have examined how metabolic health status (MHS) affects the BMI-mortality association in different age categories. We, therefore, aimed to investigate how mid- and late-life BMI and MHS interact to affect the risk of mortality. METHODS: This cohort study included 12,467 participants from the Swedish Twin Registry, with height, weight, and MHS measures from 1958-2008 and mortality data linked through 2020. We applied Cox proportional hazard regression with age as a timescale to examine how BMI categories (normal weight, overweight, obesity) and MHS (identification of MetS determined by presence/absence of hypertension, hyperglycemia, low HDL, hypertriglyceridemia), independently and in interaction, are associated with the risk of all-cause mortality. Models were adjusted for sex, education, smoking, and cardiovascular disease. RESULTS: The midlife group included 6,252 participants with a mean age of 59.6 years (range = 44.9-65.0) and 44.1% women. The late-life group included 6,215 participants with mean age 73.1 years (65.1-95.3) and 46.6% women. In independent effect models, metabolically unhealthy status in midlife increased mortality risks by 31% [hazard ratio 1.31; 95% confidence interval 1.12-1.53] and in late-life, by 18% (1.18;1.10-1.26) relative to metabolically healthy individuals. Midlife obesity increased the mortality risks by 30% (1.30;1.06-1.60) and late-life obesity by 15% (1.15; 1.04-1.27) relative to normal weight. In joint models, the BMI estimates were attenuated while those of MHS were less affected. Models including BMI-MHS categories revealed that, compared to metabolically healthy normal weight, the metabolically unhealthy obesity group had increased mortality risks by 53% (1.53;1.19-1.96) in midlife, and across all BMI categories in late-life (normal weight 1.12; 1.01-1.25, overweight 1.10;1.01-1.21, obesity 1.31;1.15-1.49). Mortality risk was decreased by 9% (0.91; 0.83-0.99) among those with metabolically healthy overweight in late-life. CONCLUSIONS: MHS strongly influenced the BMI-mortality association, such that individuals who were metabolically healthy with overweight or obesity in mid- or late-life did not carry excess risks of mortality. Being metabolically unhealthy had a higher risk of mortality independent of their BMI.
Ämnesord
- MEDICIN OCH HÄLSOVETENSKAP -- Klinisk medicin -- Geriatrik (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Clinical Medicine -- Geriatrics (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Hälsovetenskap -- Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Health Sciences -- Public Health, Global Health, Social Medicine and Epidemiology (hsv//eng)
- MEDICIN OCH HÄLSOVETENSKAP -- Annan medicin och hälsovetenskap -- Gerontologi, medicinsk/hälsovetenskaplig inriktning (hsv//swe)
- MEDICAL AND HEALTH SCIENCES -- Other Medical and Health Sciences -- Gerontology, specialising in Medical and Health Sciences (hsv//eng)
Nyckelord
- Body weight
- Metabolic syndrome
- Metabolically benign obesity
- Metabolically healthy obesity
- Mortality
- Obesity
- adult
- aged
- body mass
- cohort analysis
- complication
- female
- follow up
- human
- male
- metabolic syndrome X
- middle aged
- register
- risk factor
- Sweden
- Body Mass Index
- Cohort Studies
- Follow-Up Studies
- Humans
- Overweight
- Registries
- Risk Factors
- Välbefinnande vid långvariga hälsoproblem (WeLHP)
- Adult
- Aged
- Body Mass Index
- Cohort Studies
- Female
- Follow-Up Studies
- Humans
- Male
- Metabolic Syndrome
- complications
- epidemiology
- Middle Aged
- Obesity
- Overweight
- Registries
- Risk Factors
- Sweden
Publikations- och innehållstyp
- ref (ämneskategori)
- art (ämneskategori)
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